Evidence map›Paper›PMID 42589310›Full record

ReviewInternational journal of molecular sciences2026

From the Cosmos to the Cell: The Central Role of Iron in the Chemistry and Evolution of Life.

Paolo Arosio, Fadi Bou-Abdallah

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Paolo ArosioDepartment of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy.ORCID 0000-0002-5343-8992
Fadi Bou-AbdallahDepartment of Chemistry, State University of New York (SUNY) at Potsdam, Potsdam, NY 13676, USA.ORCID 0000-0002-8557-1827

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron, with the unique stability of its nucleus, occupies an unusual position among the elements: its abundance on Earth is not simply a geological accident but a direct consequence of nuclear reactions that happened inside stars billions of years ago. Formed at the final stages of fusion in stars, iron spread through space by supernova explosions and became part of the material that formed Earth, eventually becoming the dominant component of the planet's core. At the surface, iron's redox chemistry shaped the early atmosphere and oceans, and its availability as a soluble ferrous ion in the anaerobic Archean ocean made it a natural cofactor for the first enzymatic reactions. That same redox flexibility and the ability of iron to shuttle between Fe

Indexed as

Biological EvolutionIronOrigin of LifeOxidation-ReductionIronbiological evolutiongreat oxidation eventheme biosynthesisiron cofactorsiron homeostasisiron metabolismiron–sulfur clustersorigin of lifeprebiotic chemistryredox chemistry

Identifiers

PMID42589310
PMCPMC13466996

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.