Evidence map›Paper›PMID 42589338›Full record

ArticleInternational journal of molecular sciences2026

Effect of Ketogenic Diet Versus Vegan Diet on Obesity-Induced Testicular Dysfunction and Mediating Role of Gut Microbiota.

Sarah A Salama, Nancy H Hassan, Amina A Abdelhadi, Eman K Soliman, Amira H M Soliman, Mahmoud M Malek, Rania R A Atia, Sara R A Mohamed, Islam M Wahid, Islam M Salem and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sarah A SalamaMedical Physiology, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.ORCID 0000-0003-3078-0012
Nancy H HassanHuman Anatomy and Embryology, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.
Amina A AbdelhadiMedical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.ORCID 0000-0002-8339-1929
Eman K SolimanMedical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.ORCID 0000-0002-6017-7700
Amira H M SolimanHuman Anatomy and Embryology, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.
Mahmoud M MalekUrology and Andrology, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.
Rania R A AtiaMedical Physiology, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.ORCID 0000-0003-0363-3797
Sara R A MohamedHepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.
Islam M WahidInternal Medicine Department, Endocrinology, Faculty of Human Medicine, Zagazig University, Zagazig 44519, Egypt.
Islam M SalemInternal Medicine Department, Endocrinology, Faculty of Human Medicine, Zagazig University, Zagazig 44519, Egypt.
Dara AldisiCommunity Health Sciences Department, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.
Mahmoud M A AbulmeatyCommunity Health Sciences Department, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.ORCID 0000-0002-1779-0091
Abdalla Abdal-HayCenter for Orofacial Regeneration, Reconstruction and Rehabilitation (COR3), School of Dentistry, The University of Queensland, Brisbane 4006, Australia.ORCID 0000-0001-6307-6027
Reham M WahidMedical Physiology, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.ORCID 0000-0003-3818-2631

Funding

the Ongoing Research Funding Program (ORF-2026-716), King Saud University, Riyadh, Saudi Arabia the Ongoing Research Funding Program (ORF-2026-716), King Saud University, Riyadh, Saudi Arabia
6 · The paper itself

Abstract

Obesity is associated with metabolic dysregulation and impaired male reproductive capacity, where the gut microbiota affects male reproductive function through diverse mechanisms that warrant further elucidation. This study aims to evaluate the effects of ketogenic and vegan dietary interventions in attenuating obesity-associated testicular injury and to examine the extent to which specific gut microbiota profiles mediate their impact. Forty-nine male adult albino rats were assigned to seven groups: control group, obese group (HFD), obese group + modified microbiota, obese group + ketogenic diet, obese group + ketogenic diet + modified microbiota, obese group + vegan diet, and obese group + vegan diet + modified microbiota. Metabolic markers (glucose, insulin, leptin, and HOMA-IR), reproductive hormones (testosterone, FSH, and LH), and testicular gene expression (IL-6, eNOS, and androgen receptor) were analyzed over five months. Gut microbiota composition (qPCR) and testicular histology/immunohistochemistry were assessed. HFD-fed rats exhibited hyperglycemia, insulin resistance, hypogonadism, and testicular degeneration. Both diets improved metabolic and hormonal profiles, restored testicular architecture, and downregulated inflammatory genes. Microbiota modification additively enhanced these effects, increasing the abundance of

Indexed as

Diet, KetogenicDiet, VeganGastrointestinal MicrobiomeObesityTesticular DiseasesTestisAnimalsDiet, High-FatMaleRatsgut microbiotaketogenic dietobesitytesticular dysfunctionvegan diet

Identifiers

PMID42589338
PMCPMC13466703

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.