Evidence map›Paper›PMID 42589382›Full record

ArticleInternational journal of molecular sciences2026

PVR Mediates Resistance to IL21.CD276.CAR-T Therapy in Esophageal Squamous Cell Carcinoma.

Lihong Wang, Qijing Guo, Wenkai Han, Xiaoxuan Tao, Tong Ye, Li Sun, Yiming Gao, Anna Niu, Hui Zhao, Xiaoyan Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lihong WangDepartment of Oncology, Air Force Medical Center, People's Liberation Army, Beijing 100142, China.
Qijing GuoDepartment of Oncology, Air Force Medical Center, People's Liberation Army, Beijing 100142, China.
Wenkai HanDepartment of Oncology, Air Force Medical Center, People's Liberation Army, Beijing 100142, China.
Xiaoxuan TaoDepartment of Oncology, Air Force Medical Center, People's Liberation Army, Beijing 100142, China.
Tong YeDepartment of Oncology, Air Force Medical Center, People's Liberation Army, Beijing 100142, China.
Li SunDepartment of Oncology, Air Force Medical Center, People's Liberation Army, Beijing 100142, China.
Yiming GaoDepartment of Oncology, Air Force Medical Center, People's Liberation Army, Beijing 100142, China.
Anna NiuDepartment of Pharmacy, Air Force Medical Center, People's Liberation Army, Beijing 100036, China.
Hui ZhaoDepartment of Oncology, Air Force Medical Center, People's Liberation Army, Beijing 100142, China.
Xiaoyan LiuDepartment of Biomedical Engineering, City University of Hong Kong, Kowloon, Hong Kong SAR 999077, China.
Yu WangDepartment of Oncology, Air Force Medical Center, People's Liberation Army, Beijing 100142, China.

Funding

Air Force General Hospital PLA 2024ZXKXKT039;2025RCZZ11National Natural Science Foundation of China 82403870
6 · The paper itself

Abstract

Chimeric antigen receptor (CAR)-T therapy has achieved partial therapeutic efficacy in solid tumors, but its overall effectiveness remains limited. IL-21-armored CD276.CAR-T (IL21.CD276.CAR-T) represents a promising strategy to enhance anti-tumor activity against esophageal squamous cell carcinoma (ESCC). However, resistance mechanisms remain unclear. We generated IL21.CD276.CAR-T cells and evaluated their cytotoxicity

Indexed as

Drug Resistance, NeoplasmEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaImmunotherapy, AdoptiveInterleukinsReceptors, Chimeric AntigenReceptors, VirusAnimalsCell Line, TumorHumansInterleukin-21MiceXenograft Model Antitumor AssaysInterleukin-21Interleukinspoliovirus receptorReceptors, Chimeric AntigenReceptors, VirusCAR-T cellsCD276drug resistanceesophageal squamous cell carcinomaIL-21poliovirus receptor

Identifiers

PMID42589382
PMCPMC13466472

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.