ArticleInternational journal of molecular sciences2026
Dopamine D1-like and Angiotensin II Type 1 Receptors Counter-Regulate Autophagy and Cell Proliferation in Rat Embryonic Thoracic Vascular Smooth Muscle Cells.
Hewang Lee, Amy Lu, Waleed N Qaddumi, Bibhas Amatya, Jacob Polzin, Maithri Verma, Raisha C Cadme, Robin A Felder, Ines Armando, Jeffrey B Kopp and 1 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Hewang LeeDepartment of Medicine, Division of Kidney Disease & Hypertension, The George Washington University School of Medicine & Health Sciences, Washington, DC 20052, USA.ORCID 0000-0003-1338-2573 Amy LuDepartment of Medicine, Division of Kidney Disease & Hypertension, The George Washington University School of Medicine & Health Sciences, Washington, DC 20052, USA.
Waleed N QaddumiDepartment of Medicine, Division of Kidney Disease & Hypertension, The George Washington University School of Medicine & Health Sciences, Washington, DC 20052, USA.ORCID 0000-0003-3480-5088 Bibhas AmatyaDepartment of Medicine, Division of Kidney Disease & Hypertension, The George Washington University School of Medicine & Health Sciences, Washington, DC 20052, USA.
Jacob PolzinDepartment of Medicine, Division of Kidney Disease & Hypertension, The George Washington University School of Medicine & Health Sciences, Washington, DC 20052, USA.ORCID 0009-0000-8202-0432 Maithri VermaDepartment of Medicine, Division of Kidney Disease & Hypertension, The George Washington University School of Medicine & Health Sciences, Washington, DC 20052, USA.
Raisha C CadmeDepartment of Medicine, Division of Kidney Disease & Hypertension, The George Washington University School of Medicine & Health Sciences, Washington, DC 20052, USA.
Robin A FelderDepartment of Pathology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA.ORCID 0000-0003-2797-4289 Ines ArmandoDepartment of Medicine, Division of Kidney Disease & Hypertension, The George Washington University School of Medicine & Health Sciences, Washington, DC 20052, USA.
Pedro A JoseDepartment of Medicine, Division of Kidney Disease & Hypertension, The George Washington University School of Medicine & Health Sciences, Washington, DC 20052, USA.
Funding
FOCAL SEGMENTAL GLOMERULOSCLEROSIS--PATHOGENESIS AND TREATMENTZ01DK043308 · DIABETES, DIGESTIVE, KIDNEY DISEASES · 1997 to 2005
–National Natural Science Foundation of China 81670406National Natural Science Foundation of China 81670698National Natural Science Foundation of China 91739119NIDDK NIH HHS Z01DK043308NIH HHS 5R01DK134574-04
6 · The paper itselfAbstract
Vascular smooth muscle cells (VSMCs), the contractile cells in the tunica media of blood vessels, maintain vascular tone. The proliferation of VSMCs is an important feature of vascular remodeling that contributes to the regulation of blood pressure. Autophagy, an intracellular self-degrading process that delivers cytoplasmic constituents to lysosomes, plays a vital role in VSMC proliferation. This is regulated by the dopaminergic and renin-angiotensin systems but their interplay in their regulation of autophagy in VSMCs is not well-understood. In rat VSMCs, fenoldopam (Fen), a dopamine D1-like receptor agonist, increased autophagy, as determined by the increase in the protein expressions of microtubule-associated protein 1 light chain (LC)3-II and beclin-1 (BECN1), in a time- and concentration-dependent manner. Conversely, angiotensin II (Ang II), the endogenous Ang II type 1 receptor (AT
Indexed as
AutophagyCell ProliferationMuscle, Smooth, VascularMyocytes, Smooth MuscleReceptor, Angiotensin, Type 1Receptors, Dopamine D1Angiotensin IIAnimalsCells, CulturedCyclic AMPFenoldopamMicrotubule-Associated ProteinsRatsSignal TransductionTOR Serine-Threonine KinasesAngiotensin IICyclic AMPFenoldopamMicrotubule-Associated ProteinsReceptor, Angiotensin, Type 1Receptors, Dopamine D1TOR Serine-Threonine KinasesAng II type 1 receptorautophagycyclic AMPD1-like receptorsmTORproliferationVSMC
Identifiers
PMID42589441
PMCPMC13467237
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