ArticleInternational journal of molecular sciences2026
Atorvastatin Mitigates Hypercholesterolemia-Induced Alterations in Cerebral Mitochondrial Dehydrogenases in Rats.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Statins are widely used lipid-lowering agents for the prevention and treatment of cardiovascular disease. Atorvastatin, one of the most frequently used statins, was reported to influence mitochondrial function, including the regulation of mitochondrial enzyme activity. Our recent study demonstrated that short-term treatment with atorvastatin effectively counteracted the alterations in α-ketoglutarate dehydrogenase (α-KGDH) induced by a high-cholesterol diet. Since α-KGDH and isocitrate dehydrogenase (IDH) together with glutamate dehydrogenase (GDH) are functionally interconnected, we hypothesized that atorvastatin modulates their activity in the brain. The study aimed to evaluate the effect of short-term atorvastatin treatment on cerebral mitochondrial dehydrogenases α-KGDH, IDH and GDH in hypercholesterolemic rats. Atorvastatin at dose 20 mg/kg b·wt/day (HC+A,
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