Evidence mapPaperPMID 42589477Full record

ArticleInternational journal of molecular sciences2026

Identification of Natural Flavonoids Targeting PLK-1 as Potential Anti-Metastatic Agents: A Computational Approach.

Yudith Cañizares-Carmenate, Erix W Hernández-Rodríguez, Yunier Perera-Sardiña, Dina B Aguado-Herrera, Roberto Díaz-Amador, Francisco Torrens, Juan A Castillo-Garit

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yudith Cañizares-CarmenateLaboratorio de Bioinformática y Química Computacional, Departamento de Medicina Traslacional, Facultad de Medicina, Universidad Católica del Maule, Talca 3460000, Chile.
Erix W Hernández-RodríguezLaboratorio de Bioinformática y Química Computacional, Departamento de Medicina Traslacional, Facultad de Medicina, Universidad Católica del Maule, Talca 3460000, Chile.ORCID 0000-0002-9231-7552
Yunier Perera-SardiñaLaboratory of Pharmacology and Physiology, Department of Basic Biomedical Sciences, Faculty of Health Sciences, University of Talca, Talca 3460000, Chile.ORCID 0000-0001-8205-2565
Dina B Aguado-HerreraUnit of Computer-Aided Molecular "Biosilico" Discovery and Bioinformatic Research (CAMD-BIR Unit), Departamento de Farmacia, Facultad Química y Farmacia, Universidad Central ''Marta Abreu" de Las Villas, Santa Clara 54830, Villa Clara, Cuba.
Roberto Díaz-AmadorLaboratorio de Bioinformática y Química Computacional, Departamento de Medicina Traslacional, Facultad de Medicina, Universidad Católica del Maule, Talca 3460000, Chile.
Francisco TorrensInstitut Universitari de Ciència Molecular, Universitat de València, Edifici d'Instituts de Paterna, P.O. Box 22085, 46071 Valencia, Spain.ORCID 0000-0002-8534-208X
Juan A Castillo-GaritInstituto Universitario de Investigación y Desarrollo Tecnológico (IDT), Universidad Tecnológica Metropolitana, Ignacio Valdivieso 2409, San Joaquín, Santiago 8940577, Chile.ORCID 0000-0003-0896-9484

Funding

National Agency for Research and Development 3250840
6 · The paper itself

Abstract

This study combines ligand- and structure-based

Indexed as

Antineoplastic AgentsCell Cycle ProteinsFlavonoidsProtein Kinase InhibitorsProtein Serine-Threonine KinasesProto-Oncogene ProteinsHumansMolecular Docking SimulationMolecular Dynamics SimulationPolo-Like Kinase 1Antineoplastic AgentsCell Cycle ProteinsFlavonoidsPolo-Like Kinase 1Protein Kinase InhibitorsProtein Serine-Threonine KinasesProto-Oncogene Proteinscancer treatmentdockingmolecular dynamics simulationpolo-like kinase-1 inhibitorvirtual screening

Identifiers

PMID42589477
PMCPMC13466354

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.