Evidence mapPaperPMID 42589481Full record

ArticleInternational journal of molecular sciences2026

Opposing Roles of CYP2E1 and ALDH2 in Binge Alcohol-Mediated Cerebellar Damage.

Leon Ruiter-Lopez, Wiramon Rungratanawanich, Byoung-Joon Song

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Leon Ruiter-LopezSection of Molecular Pharmacology and Toxicology, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.ORCID 0000-0001-9056-1116
Wiramon RungratanawanichSection of Molecular Pharmacology and Toxicology, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.ORCID 0000-0001-9334-0984
Byoung-Joon SongSection of Molecular Pharmacology and Toxicology, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.ORCID 0000-0002-3954-3497

Funding

NIH HHS 1R01AA000036
6 · The paper itself

Abstract

To explore the opposing roles between the toxic acetaldehyde-producing enzyme Cytochrome P450-2E1 (CYP2E1) and acetaldehyde-clearing protein mitochondrial Aldehyde Dehydrogenase-2 (ALDH2) in alcohol-mediated cerebellar damage, two separate experiments were conducted. Young Svj/129 wild-type (WT) vs.

Indexed as

Aldehyde Dehydrogenase, MitochondrialBinge DrinkingCerebellumCytochrome P-450 CYP2E1EthanolAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutNeuronsOxidative StressProtein Processing, Post-TranslationalAldehyde Dehydrogenase, MitochondrialALDH2 protein, mouseCytochrome P-450 CYP2E1EthanolalcoholALDH2cerebellumCYP2E1locomotor testneuronal damageoxidative stresspost-translational modifications

Identifiers

PMID42589481
PMCPMC13466411

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.