ArticleInternational journal of molecular sciences2026
A Cell-Based Therapeutic Strategy for Stress Urinary Incontinence: Functional and Molecular Evidence from Decidua-Derived Mesenchymal Stromal Cells.
Paz de la Torre, Jennifer Collado, Mª José Morán-Jiménez, Laura Forcén, Ana R Masero-Casasola, Alicia García, Mª Carmen Gutiérrez-Vélez, José Medina-Polo, Eloy Muñoz, José Joaquín Merino and 1 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Paz de la TorreGrupo de Medicina Regenerativa, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.ORCID 0000-0002-5816-4396 Jennifer ColladoGrupo de Medicina Regenerativa, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.ORCID 0000-0003-2187-2919 Mª José Morán-JiménezGrupo de Medicina Regenerativa, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.ORCID 0000-0003-3755-5934 Laura ForcénGrupo de Medicina Regenerativa, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.
Ana R Masero-CasasolaGrupo de Medicina Regenerativa, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.
Alicia GarcíaGrupo de Medicina Regenerativa, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.
Mª Carmen Gutiérrez-VélezGrupo de Medicina Regenerativa, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.
José Medina-PoloGrupo de Salud Integral Masculina, Instituto de Investigación Hospital 12 de Octubre (imas12) y Servicio de Urología, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.ORCID 0000-0003-3626-8669 Eloy MuñozGrupo de Medicina Regenerativa, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.
José Joaquín MerinoGrupo de Medicina Regenerativa, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.
Ana I FloresGrupo de Medicina Regenerativa, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.ORCID 0000-0002-5019-0434 Funding
Community of Madrid PEJ16/MED/TL-1388, PEJ-2020-TL/BMD-19230, PEJ-2024-AI/SAL-GL-33566Institute of Health Carlos III PI15/01803, PI18/01278, and DTS22-00166MCIN/AEI/10.13039/501100011033/ FEDER PID2022-140785OB-I00
6 · The paper itselfAbstract
Stress urinary incontinence (SUI) is a highly prevalent condition associated with pelvic floor damage, fibroblast dysfunction, and impaired extracellular matrix (ECM) remodeling. This study aimed to investigate the regenerative potential and underlying molecular mechanisms of decidua-derived mesenchymal stromal cells (DMSCs) in a rat model of vaginal distension (VD) and in human suburethral fibroblasts from SUI patients. Adult female rats were subjected to VD and treated with periurethral DMSC injections, followed by functional and transcriptomic analyses, one and six weeks after VD. In parallel, an in vitro co-culture system was used to evaluate the paracrine effects of DMSCs on SUI fibroblasts. DMSC treatment significantly increased leak point pressure (LPP) one week after VD, approaching values observed in control animals (19.8 ± 0.45 vs. 22.3 ± 2.08 mmHg,
Indexed as
Cell- and Tissue-Based TherapyDeciduaMesenchymal Stem CellsMesenchymal Stem Cell TransplantationUrinary Incontinence, StressAnimalsCoculture TechniquesExtracellular MatrixFemaleFibroblastsHumansRatsUrethradecidua-derived mesenchymal stromal cells (DMSCs)endopelvic fasciaextracellular matrix (ECM)fibroblastperinatal mesenchymal stromal cellsregenerative medicinesenescencestress urinary incontinence (SUI)tissue regenerationurethral functionvaginal distension
Identifiers
PMID42589501
PMCPMC13467398
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