Evidence map›Paper›PMID 42589513›Full record

ArticleInternational journal of molecular sciences2026

High-Intensity Interval Training Snacks Improve Experimental Autoimmune Encephalomyelitis.

Oswaldo C Junior, Jully C S Viana, Lorranna E A Teixeira, Luiz G V Filho, Maria E H Corrêa, Mariana F Andrade, Ana C F Sperandio, Giovanna P Caetano, Philipe L Brito, Maiara R Salvador and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Oswaldo C JuniorFaculdade de Medicina, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Teófilo Otoni 39803-371, MG, Brazil.
Jully C S VianaFaculdade de Medicina, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Teófilo Otoni 39803-371, MG, Brazil.
Lorranna E A TeixeiraFaculdade de Medicina, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Teófilo Otoni 39803-371, MG, Brazil.
Luiz G V FilhoFaculdade de Medicina, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Teófilo Otoni 39803-371, MG, Brazil.
Maria E H CorrêaFaculdade de Medicina, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Teófilo Otoni 39803-371, MG, Brazil.
Mariana F AndradeFaculdade de Medicina, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Teófilo Otoni 39803-371, MG, Brazil.
Ana C F SperandioFaculdade de Medicina, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Teófilo Otoni 39803-371, MG, Brazil.
Giovanna P CaetanoFaculdade de Medicina, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Teófilo Otoni 39803-371, MG, Brazil.
Philipe L BritoFaculdade de Medicina, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Teófilo Otoni 39803-371, MG, Brazil.ORCID 0000-0001-5289-1886
Maiara R SalvadorInstituto de Ciências da Vida, Universidade Federal de Juiz de Fora-Campus Avançado Governador Valadares, Governador Valadares 35032-620, MG, Brazil.ORCID 0000-0003-1677-2817
Liliane S PinheiroFaculdade de Medicina, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Teófilo Otoni 39803-371, MG, Brazil.
Marco Fabrício Dias-PeixotoDepartamento de Educação Física, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina 39100-000, MG, Brazil.ORCID 0000-0003-3324-3634
Alessandra P CarliInstituto de Ciência Engenharia e Tecnologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Teófilo Otoni 39803-371, MG, Brazil.
Caio César de Souza AlvesFaculdade de Medicina, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Teófilo Otoni 39803-371, MG, Brazil.ORCID 0000-0001-9765-8527
Sandra B R CastroFaculdade de Medicina, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Teófilo Otoni 39803-371, MG, Brazil.ORCID 0000-0002-5535-0919

Funding

Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ 02052/21; APQ 02056/22; APQ-00607-22; APQ 02762/25; APQ-01160-26
6 · The paper itself

Abstract

Several studies have shown that physical activity is associated with increased life expectancy and the prevention of chronic and neurodegenerative diseases. This study aimed to evaluate the impact of high-intensity interval training (HIIT) on the progression of an experimental model of multiple sclerosis. For this purpose, the murine model of experimental encephalomyelitis (EAE) was used in female C57BL/6 mice, divided into four groups: negative control (CN), positive control (EAE), HIIT once a day (1-HIIT), and HIIT snacks, three times a day (3-HIIT). The clinical score results demonstrated a significant reduction in the clinical score in mice subjected to 3-HIIT, confirmed by analyses of pro- and anti-inflammatory cytokines and histological analyses. These results provided solid evidence for the potential of HIIT protocols, especially 3-HIIT, to reprogram an autoimmune response in the CNS in mice with the EAE model, favoring a neuroprotective and immunoregulatory environment-evidence that may drive clinical research.

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalHigh-Intensity Interval TrainingPhysical Conditioning, AnimalAnimalsCytokinesDisease Models, AnimalFemaleMiceMice, Inbred C57BLMultiple SclerosisCytokines3-HIITand immunomodulationmultiple sclerosis

Identifiers

PMID42589513
PMCPMC13467572

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.