Evidence map›Paper›PMID 42589529›Full record

ArticleInternational journal of molecular sciences2026

Metabolism Pathway Blood Proteomic Differences in Lewy Body Dementia Compared to Alzheimer's Disease.

Ariana N Pritha, Leonidas Chouliaras, Peter Swann, Maria Prats-Sedano, Anna McKeever, Amanda Heslegrave, Nicholas J Ashton, Henrik Zetterberg, Li Su, Maura Malpetti and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ariana N PrithaDepartment of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK.
Leonidas ChouliarasDepartment of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK.
Peter SwannDepartment of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK.
Maria Prats-SedanoDepartment of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK.
Anna McKeeverDepartment of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK.
Amanda HeslegraveDementia Research Institute, University College London, London NW1 3BT, UK.
Nicholas J AshtonDepartment of Psychiatry and Neurochemistry, University of Gothenburg, 405 30 Gothenburg, Sweden.
Henrik ZetterbergDementia Research Institute, University College London, London NW1 3BT, UK.
Li SuDepartment of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK.ORCID 0000-0002-6347-3986
Maura MalpettiDepartment of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK.
James B RoweDepartment of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK.
John T O'BrienMedical Research Council Cognition and Brain Sciences Unit, Cambridge CB2 7EF, UK.ORCID 0000-0002-0837-5080

Funding

Medical Research Council MC_UU_00030/14Medical Research Council MR/T033371/1NIHR Cambridge Biomedical Research Centre NIHR203312Race Against Dementia Alzheimer's Research UK ARUK-RADF2021A-010
6 · The paper itself

Abstract

Dementia with Lewy Bodies (DLB) is the most common neurodegenerative dementia after Alzheimer's disease (AD), but it remains challenging to diagnose due to overlapping symptoms and mixed pathologies. This pilot study tested whether DLB has different metabolic blood proteomic profiles compared to AD and controls. Serum was analysed from people with DLB (

Indexed as

Alzheimer DiseaseLewy Body DiseaseMetabolic Networks and PathwaysProteomeProteomicsAgedAged, 80 and overBiomarkersFemaleHumansMaleBiomarkersProteomeAlzheimer’s diseaseDementia with Lewy Bodies (DLB)protein blood biomarkersproteomics

Identifiers

PMID42589529
PMCPMC13467508

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.