Observational studyInternational journal of molecular sciences2026
Oxidative Stress Biomarkers and Their Association with Interleukin-6 in Patients with Obstructive Sleep Apnea: A Cross-Sectional Study.
Observational study in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Oxidative stress and systemic inflammation are considered key mechanisms linking obstructive sleep apnea (OSA) to cardiovascular disease. This study aimed to investigate the relationships among oxidative stress, nitrosative stress, inflammatory biomarkers, and echocardiographic alterations in OSA. This cross-sectional observational study included 72 adults with OSA, classified according to disease severity as mild, moderate, or severe. Clinical characteristics and echocardiographic parameters were assessed. Oxidative stress biomarkers-malondialdehyde (MDA), total oxidant status (TOS), total antioxidant capacity (TAC), nitric oxide (NO), oxidative stress index (OSI), and paraoxonase-1 (PON1); the nitrosative stress marker 3-nitrotyrosine (3-NT), inflammatory biomarkers-interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α); and N-terminal pro-B-type natriuretic peptide (NT-proBNP)-were determined using spectrophotometric and ELISA methods. Correlation and regression analyses were performed to evaluate associations between oxidative stress and inflammation. No significant differences in echocardiographic parameters, oxidative stress biomarkers, inflammatory markers, or NT-proBNP concentrations were observed across OSA severity categories (all
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