Evidence map›Paper›PMID 42589606›Full record

ArticleInternational journal of molecular sciences2026

Biological Evaluation, Molecular Docking, and in Ovo Hatchability Assessment of Selected Mannich-Type 1,2,4-Triazol-5-one Derivatives.

Songül Ulufer Bulut, Özlem Durna, Songül Boy, Fevzi Aytemiz, Gül Özdemir Toraman, Önder Albayrak, Murat Beytur, Ahmet Harmankaya, Haydar Yüksek, Gültekin Yildiz

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Songül Ulufer BulutPharmacy Services Department, Kağızman Vocational School, Kafkas University, Kars 36700, Türkiye.
Özlem DurnaAnimal Nutrition and Nutritional Diseases Department, Veterinary Faculty, Dicle University, Diyarbakır 21280, Türkiye.ORCID 0000-0003-4532-6795
Songül BoyMedical Services and Techniques Department, Atatürk Health Services Vocational School, Kafkas University, Kars 36000, Türkiye.
Fevzi AytemizMedical Services and Techniques Department, Atatürk Health Services Vocational School, Kafkas University, Kars 36000, Türkiye.ORCID 0000-0002-5982-9038
Gül Özdemir ToramanDepartment of Chemistry, Faculty of Science and Letters, Kafkas University, Kars 36000, Türkiye.
Önder AlbayrakMedical Services and Techniques Department, Atatürk Health Services Vocational School, Kafkas University, Kars 36000, Türkiye.
Murat BeyturDepartment of Chemistry, Faculty of Science and Letters, Kafkas University, Kars 36000, Türkiye.
Ahmet HarmankayaDepartment of Chemistry, Faculty of Science and Letters, Kafkas University, Kars 36000, Türkiye.
Haydar YüksekDepartment of Chemistry, Faculty of Science and Letters, Kafkas University, Kars 36000, Türkiye.
Gültekin YildizAnimal Nutrition and Nutritional Diseases Department, Veterinary Faculty, Ankara University, Kars 06100, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1,2,4-Triazole derivatives are widely investigated as bioactive heterocyclic compounds with diverse biological properties; however, their potential effects on avian embryonic development remain insufficiently characterized. This study aimed to synthesize selected Mannich-type 1,2,4-triazol-5-one derivatives and evaluate their in vitro biological activities, predicted enzyme interactions, and in ovo hatchability outcomes in broiler embryos. Three derivatives (

Indexed as

Molecular Docking SimulationTriazolesAnimalsCarbonic Anhydrase IICatalaseChick EmbryoChickensFree Radical ScavengersCarbonic Anhydrase IICatalaseFree Radical ScavengersTriazoles1,2,4-triazol-5-one derivativesantimicrobial activityantioxidant-related activityhatchabilityin ovoMannich basesmetal chelationmolecular docking

Identifiers

PMID42589606
PMCPMC13467072

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.