Evidence map›Paper›PMID 42589607›Full record

ArticleInternational journal of molecular sciences2026

Upregulated Renal Mineralocorticoid Receptor and 11β-Hydroxysteroid Dehydrogenase Type 2 Are Associated with K

Irina Baranovskaya, Iryna Bilous, Sati Alexander, Bianca Tubalinal, Alena Cherezova, Vadym Buncha, Mikhail Fomin, Celso Gomez-Sanchez, Mykola Mamenko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Irina BaranovskayaImmunology Center of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-4573-8466
Iryna BilousDepartment of Physiology, Augusta University, Augusta, GA 30912, USA.
Sati AlexanderDepartment of Physiology, Augusta University, Augusta, GA 30912, USA.
Bianca TubalinalCollege of Allied Health Sciences, Augusta University, Augusta, GA 30912, USA.
Alena CherezovaDepartment of Physiology, Augusta University, Augusta, GA 30912, USA.
Vadym BunchaDepartment of Physiology & Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Mikhail FominImmunology Center of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0009-0005-5248-5817
Celso Gomez-SanchezDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Mykola MamenkoDepartment of Physiology, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0001-8683-0715

Funding

Sex disparities in aldosterone-dependent renal Na+ transport and blood pressure controlR01DK125464 · NIDDK · AUGUSTA UNIVERSITY · PI MAMENKO, MYKOLA · 2021 to 2025
$1.9M
NIDDK NIH HHS R01 DK125464NIDDK NIH HHS R01DK125464
6 · The paper itself

Abstract

Mineralocorticoid receptor (MR) blockade exerts sex-specific effects in hypertension and cardiovascular disease; however, its role in blood pressure regulation in spontaneously hypertensive rats (SHRs) remains unclear. We assessed the effects of MR antagonism on blood pressure and electrolyte balance in male and female SHRs aged 10-15 weeks. Higher serum K

Indexed as

11-beta-Hydroxysteroid Dehydrogenase Type 2HypertensionKidneyMineralocorticoid Receptor AntagonistsPotassiumReceptors, MineralocorticoidAldosteroneAnimalsBlood PressureEpithelial Sodium ChannelsFemaleMaleRatsRats, Inbred SHRRats, Inbred WKYRenin11-beta-Hydroxysteroid Dehydrogenase Type 2AldosteroneEpithelial Sodium ChannelsMineralocorticoid Receptor AntagonistsPotassiumReceptors, MineralocorticoidReninSpironolactone11β-hydroxysteroid dehydrogenase type 2hypertensionmineralocorticoid antagonismmineralocorticoid receptorpotassiumrenin–angiotensin–aldosterone systemspontaneously hypertensive rat

Identifiers

PMID42589607
PMCPMC13467425

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.