ArticleInternational journal of molecular sciences2026
Plasma Metabolic Features Associated with Developmental Regression in Autism Spectrum Disorder: A Pilot Untargeted Metabolomics Study.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Developmental regression, the loss of previously acquired language and social skills during the second year of life, affects 20-40% of children with autism spectrum disorder (ASD), yet its metabolic underpinnings remain poorly defined. Existing metabolomics studies have focused on amino acid and acylcarnitine alterations, leaving the eicosanoid, sphingolipid, and glycoconjugate axes largely unexamined. Plasma from 25 children with regressive ASD (REG+), 27 with non-regressive ASD (REG-), and 21 typically developing controls (aged 2-6 years) was profiled using untargeted Q-TOF LC/MS (Agilent 6530, ESI+ mode, 100-1700
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