Evidence map›Paper›PMID 42589668›Full record

ArticleInternational journal of molecular sciences2026

Metabolomic Insights on Obesity and Diabetes from Feeding Diets Varying in Carbohydrate-Fat Ratios in Zucker Diabetic Fatty (ZDF) and Lean Zucker (Z

Mohd Naeem Mohd Nawi, Ranina Radzi, Azizan Ali, Siti Zubaidah Che Lem, Azlina Zulkapli, Ezarul Faradianna Lokman, Mansor Fazliana, Fatin Saparuddin, Norazlan Mohmad Misnan, Sreelakshmi Sankara Narayanan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mohd Naeem Mohd NawiNutrition, Metabolism and Cardiovascular Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Setia Alam 40170, Malaysia.ORCID 0000-0002-3391-017X
Ranina RadziNutrition, Metabolism and Cardiovascular Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Setia Alam 40170, Malaysia.
Azizan AliGood Laboratory Practice Section, Herbal Medicine Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Kuala Lumpur 50588, Malaysia.
Siti Zubaidah Che LemLaboratory Animal Resource Unit, Special Resource Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Kuala Lumpur 50588, Malaysia.
Azlina ZulkapliLaboratory Animal Resource Unit, Special Resource Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Kuala Lumpur 50588, Malaysia.
Ezarul Faradianna LokmanNutrition, Metabolism and Cardiovascular Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Setia Alam 40170, Malaysia.
Mansor FazlianaNutrition, Metabolism and Cardiovascular Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Setia Alam 40170, Malaysia.
Fatin SaparuddinNutrition, Metabolism and Cardiovascular Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Setia Alam 40170, Malaysia.ORCID 0000-0002-5024-472X
Norazlan Mohmad MisnanHerbal Medicine Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Setia Alam 40170, Malaysia.ORCID 0000-0003-0942-9543
Sreelakshmi Sankara NarayananSchool of Biosciences, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya 47500, Malaysia.
Karuthan ChinnaInstitute of Research, Development and Innovation, IMU University, Kuala Lumpur 57000, Malaysia.
Mohd Fairulnizal Md NohNutrition, Metabolism and Cardiovascular Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Setia Alam 40170, Malaysia.ORCID 0000-0001-6960-0774
Zulfitri Azuan Mat DaudDepartment of Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia.ORCID 0000-0002-4017-107X
Tilakavati KarupaiahJeffrey Cheah School of Medicine & Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway 47500, Malaysia.ORCID 0000-0001-5808-8074

Funding

Ministry of Health NMRR-20-413-5300
6 · The paper itself

Abstract

In population health the highly cited Atherosclerosis Risk in Communities study indicated a U-shaped association between carbohydrate intake and mortality, whilst the Prospective Urban Rural Epidemiology study linked higher fat intake to lower mortality risks. The Malaysia Lipid Study reported high-fat and high-carbohydrate dietary patterns were associated with increased cardiometabolic risks, including insulin resistance and small dense LDL particles generation. This animal model study therefore was purposely designed to evaluate metabolic outcomes of carbohydrate-fat permutations in Zucker diabetic fatty (ZDF) and Zucker lean (Z

Indexed as

Diabetes Mellitus, ExperimentalDietary CarbohydratesDietary FatsMetabolomeMetabolomicsObesityAnimalsDiet, High-FatMaleMetforminRatsRats, ZuckerDietary CarbohydratesDietary FatsMetformindiabetesdietarymetabolomicsmetforminobesity

Identifiers

PMID42589668
PMCPMC13466821

What Socratic holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.