ArticleInternational journal of molecular sciences2026
Proteomic Characterization of Replication Stress and Impaired Antioxidant Defense in Tacrolimus-Induced Chronic Nephrotoxicity.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Tacrolimus (TAC) nephropathy is a major complication of immunosuppressive therapy and contributes to chronic kidney disease (CKD) progression through ischemia, metabolic dysfunction, and oxidative stress; however, its protein-level basis remains unclear. This study sought to identify characteristic molecular alterations in renal cortices of TAC-treated mice, so as to clarify the link between replication stress responses and metabolic dysfunction. A previously generated proteomic dataset from a TAC-induced chronic nephrotoxicity mouse model was analyzed using a protein-centered analytical strategy, including statistical, Gene Ontology, pathway, upstream regulator, and disease-enrichment analyses. A total of 7466 proteins were quantified. Upregulated proteins included KAT6A and NCKAP1, whereas downregulated proteins included NDUFC2, HSD17B12, and TECR. Coordinated impairment of CoQ
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