ArticleInternational journal of molecular sciences2026
Hepatic SIRT6 Deficiency Accelerates Female-Specific Aging Through SULT1E1-Mediated Estrogen Depletion.
Yonghui Liu, Ziliang Zhang, Tingting Wang, Xiuyan Yang, Qiufen Zhang, Xinyi Liu, Xuefeng Lu, Jian Zhang, Li Feng
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In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Yonghui LiuSchool of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.
Ziliang ZhangDepartment of Pharmaceutical and Artificial-Intelligence Sciences, Institute of Medical Artificial Intelligence, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Tingting WangDepartment of Pharmaceutical and Artificial-Intelligence Sciences, Institute of Medical Artificial Intelligence, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Xiuyan YangDepartment of Pharmaceutical and Artificial-Intelligence Sciences, Institute of Medical Artificial Intelligence, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Qiufen ZhangDepartment of Pharmaceutical and Artificial-Intelligence Sciences, Institute of Medical Artificial Intelligence, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Xinyi LiuDepartment of Pharmaceutical and Artificial-Intelligence Sciences, Institute of Medical Artificial Intelligence, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Xuefeng LuDepartment of Pharmaceutical and Artificial-Intelligence Sciences, Institute of Medical Artificial Intelligence, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Li FengDepartment of Pharmaceutical and Artificial-Intelligence Sciences, Institute of Medical Artificial Intelligence, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID 0000-0002-4021-4762 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Sexual dimorphism is a fundamental feature of aging, yet the liver-centric mechanisms underlying sex-specific aging trajectories remain incompletely understood. SIRT6, a NAD
Indexed as
AgingEstrogensLiverSirtuinsSulfotransferasesAnimalsFemaleHepatocytesMaleMiceMice, KnockoutEstrogensestrone sulfotransferaseSirt6 protein, mouseSirtuinsSulfotransferasescellular senescenceestrogen metabolismliver agingMDL-800sexual dimorphismSIRT6SULT1E1
Identifiers
PMID42589691
PMCPMC13467427
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