ArticlePediatric pulmonology2026
Impact of Thermodilution on Indexed Pulmonary Vascular Resistance Calculations in Pediatric Pulmonary Arterial Hypertension.
Article in Pediatric pulmonology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAccurate assessment of pulmonary vascular resistance index (PVRi) is essential for the diagnosis and management of pulmonary arterial hypertension (PAH). PVRi depends on pulmonary blood flow (Qp), which can be determined by thermodilution or the Fick principle. However, agreement between these methods in children with PAH remains poorly characterized.
methodsWe performed a retrospective single-center study of 209 cardiac catheterizations in 50 pediatric patients with WHO Group 1 PAH. Thermodilution-derived Qp was obtained in patients without significant intracardiac shunting and compared with Fick-derived Qp using reported oxygen consumption (VO
resultsThermodilution-derived PVRi was, on average, 2.0 Wood units·m
conclusionsThermodilution systematically yields lower PVRi than the Fick method in pediatric PAH, particularly in patients with higher PVRi. These findings highlight the importance of maintaining a consistent method of Qp determination during serial catheterizations to improve interpretation of longitudinal hemodynamic changes and clinical decision-making.
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