ArticleFrontiers in cardiovascular medicine2026
Time-dependent responses of brain injury biomarkers after severe cerebral desaturation in paediatric patients during cardiac surgery with cardiopulmonary bypass: a single-centre observational cohort study.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Neurological injury remains an important concern in paediatric patients after congenital heart disease (CHD) surgery with cardiopulmonary bypass (CPB). Regional cerebral oxygen saturation (rScO Methods: This single-centre observational cohort study included 104 children who underwent congenital heart surgery with CPB. The maximum intraoperative decrease in rScO Results: Children in the severe group were younger than those in the non-severe group, but most of the perioperative characteristics were similar. Severe desaturation was not associated with the composite inflammation score. In contrast, severe desaturation was independently associated with a higher postoperative composite brain injury score in both the LMM and the GEEs. The strongest difference between the severe and non-severe groups occurred on POD1 and remained significant after false discovery rate correction. Single-marker analyses showed directionally positive postoperative responses for GFAP, S100B, and NSE. Conclusions: A maximum intraoperative decrease in rScO
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