SynthesisFrontiers in cellular neuroscience2026
Integrated meta-analysis of human astrocytes transcriptomes reveals a candidate recurrent inflammatory signature in response to inflammatory and immune stimuli.
Synthesis in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Astrocytes are key regulators of inflammatory and immune responses in the central nervous system, particularly under pathological conditions. We conducted a systematic search of the NCBI GEO and ENA databases to identify transcriptomic studies of stimulated astrocytes. This meta-analysis integrates 11 RNA-Seq datasets, encompassing a total of 153 samples (91 stimulated, and 62 controls) exposed to pro-inflammatory stimuli such as cytokines (TNF-α, IL-6, and IL-1β), palmitic acid, and pathogens like SARS-CoV-2 and
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