ArticleFrontiers in pediatrics2026
Analysis of the pathogen spectrum, co-infection characteristics, and risk of severe disease in community-acquired pneumonia among children in Henan province.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To analyze the pathogen spectrum, co-infection characteristics, and risk factors for severe pneumonia in children with community-acquired pneumonia (CAP) in Henan Province. Methods: This study included 2,149 pediatric inpatients with CAP admitted to the Third Affiliated Hospital of Zhengzhou University from June 2023 to June 2025. Throat swab samples were tested using multiplex polymerase chain reaction (PCR) for 11 respiratory pathogens. Combined with culture results, the pathogen spectrum and co-infection characteristics were analyzed, and risk factors for severe pneumonia were identified using multivariate logistic regression analysis. It should be noted that a positive throat-swab PCR result cannot unambiguously differentiate pathogenic infection from colonization, prior infection, or asymptomatic carriage; this inherent limitation was taken into account during data interpretation. Results: The overall pathogen detection rate was 89.34%, with Conclusion: From June 2023 to June 2025, the pathogen spectrum of CAP in children in Henan Province was dominated by
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