Evidence map›Paper›PMID 42591939›Full record

ArticleInternational journal of tryptophan research : IJTR2026

Systematic Screening of Tryptophan Metabolism Identifies Site- and Microbiota-Dependent Signatures of Tryptophan Utilization in Experimental Colitis.

Lina Wehkamp, Abrar I Alsaadi, Danielle M M Harris, Meiping Yu, Taous Mekdoud, Johanna Bornhäuser, Eva Springer, Clara Gilloteau, Anant A Pothakamury, Jaclyn D Smith and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of tryptophan research : IJTR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Lina WehkampInstitute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.ORCID https://orcid.org/0009-0008-3779-623X
Abrar I AlsaadiDepartment of Biochemistry and Molecular Biology, The Huck Institute of the Life Sciences, Pennsylvania State University, University Park, PA, USA.
Danielle M M HarrisNova Scotia Government, Department of Health and Wellness, Halifax, NS, Canada.
Meiping YuInstitute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Taous MekdoudInstitute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Johanna BornhäuserInstitute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Eva SpringerInstitute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Clara GilloteauDepartment of Biochemistry and Molecular Biology, The Huck Institute of the Life Sciences, Pennsylvania State University, University Park, PA, USA.
Anant A PothakamuryDepartment of Biochemistry and Molecular Biology, The Huck Institute of the Life Sciences, Pennsylvania State University, University Park, PA, USA.
Jaclyn D SmithDepartment of Biochemistry and Molecular Biology, The Huck Institute of the Life Sciences, Pennsylvania State University, University Park, PA, USA.
Brenita C JenkinsDepartment of Biochemistry and Molecular Biology, The Huck Institute of the Life Sciences, Pennsylvania State University, University Park, PA, USA.
Martina GuggeisInstitute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Felix SommerInstitute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Silvio WaschinaInstitute for Human Nutrition and Food Science, Nutriinformatics, Kiel University, Germany.
Philip RosenstielInstitute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Stefan SchreiberInstitute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Melanie R McReynoldsDepartment of Biochemistry and Molecular Biology, The Huck Institute of the Life Sciences, Pennsylvania State University, University Park, PA, USA.
Konrad AdenInstitute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.ORCID https://orcid.org/0000-0003-3482-7316

Funding

Research Training in Physiological Adaptations to StressT32GM108563 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CANTORNA, MARGHERITA T, KORZICK, DONNA HOPE · 2014 to 2023
$2.2M
NIGMS NIH HHS T32 GM108563
6 · The paper itself

Abstract

Background: Altered tryptophan (Trp) metabolism and disrupted nicotinamide adenine dinucleotide (NAD Methods: We used targeted metabolomics to systematically profile Trp- and NAD Results: Microbial depletion significantly attenuated colitis and increased host Trp bioavailability, implicating the gut microbiota as a competitive Trp consumer. In DSS colitis, Trp degradation along the kynurenine pathway (KP) was exaggerated but blocked at the key KP enzyme quinolinate phosphoribosyltransferase (QPRT), resulting in mucosal NAD(H) depletion. ABX co-treatment normalized metabolite conversion along the KP and restored mucosal NAD(H) levels, revealing a dual role of the gut microbiota during colitis: while they compete with the host for Trp utilization, they simultaneously shape host KP regulation and NAD Conclusion: Our findings demonstrate that mucosal NAD

Indexed as

antibioticsDSS colitisgut microbiotaIBDmetabolismNADtryptophan

Identifiers

PMID42591939
PMCPMC13462615

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.