ArticleFrontiers in cardiovascular medicine2026
Impact of obstructive sleep apnea on arrhythmic risk in ischemic heart disease and hypertrophic cardiomyopathy: insights from a large national cohort.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Obstructive sleep apnea (OSA) is a prevalent sleep-disordered breathing condition associated with atrial fibrillation (AF) and cardiovascular morbidity. Its impact on life-threatening arrhythmic events, including cardiac arrest (CA) and ventricular fibrillation (VF), in patients with ischemic heart disease (IHD) and hypertrophic cardiomyopathy (HCM) remains incompletely understood. Objectives: We aimed to evaluate the association between OSA and arrhythmic outcomes in patients with IHD or HCM and to explore the potential role of AF as an intermediate pathway. Methods: Using the National Inpatient Sample (2016-2020), we identified adults with IHD or HCM. OSA and arrhythmic events were defined by ICD-10 codes. Baseline characteristics were compared, and 1:1 propensity score matching (PSM) was performed. Multivariate logistic regression assessed the relationship between OSA and AF, AF and the composite endpoint of CA/VF, and the combined effect of OSA and AF in hierarchical models. Odds ratios (ORs) with 95% confidence intervals (CIs) were reported. Results: Among 20,590 patients, 3,974 (19.3%) had OSA. OSA was independently associated with AF (OR 1.37, 95% CI 1.15-1.62, Conclusions: In patients with IHD or HCM, OSA was associated with a higher prevalence of AF, which may represent an important intermediate pathway associated with life-threatening arrhythmic events.
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