Evidence map›Paper›PMID 42592079›Full record

ArticleBrain communications2026

Cortical excitability stratifies neurochemical profiles in amyotrophic lateral sclerosis.

Sicong Tu, Colin J Mahoney, William Huynh, Steve Vucic, Matthew C Kiernan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sicong TuBrain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia.ORCID https://orcid.org/0000-0002-6914-6660
Colin J MahoneyBrain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia.
William HuynhBrain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia.
Steve VucicBrain and Nerve Research Centre, Concord Clinical School, The University of Sydney, Sydney, NSW 2139, Australia.
Matthew C KiernanNeuroscience Research Australia, Scientia Professor of Neuroscience, University of NSW, Sydney, NSW 2031, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transsynaptic deficits arising from an imbalance in excitatory/inhibitory inter-neuronal circuitry have been extensively shown to underlie the phenomena of altered cortical motor excitability in patients with amyotrophic lateral sclerosis (ALS), with glutamate-induced excitotoxicity believed to represent a primary mechanism of ALS pathogenesis.

Indexed as

amyotrophic lateral sclerosiscortical excitabilitymagnetic resonance spectroscopymotor neuron diseasethreshold-tracking TMS

Identifiers

PMID42592079
PMCPMC13464032

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.