Evidence map›Paper›PMID 42592280›Full record

ArticleVirus evolution2026

Genomic evolution and minority variant dynamics of RSV during the first season of nirsevimab implementation in Italy (2024-5).

Greta Romano, Roberta Campagna, Guglielmo Ferrari, Antonino Maria Guglielmo Pitrolo, Ombretta Turriziani, Matteo Fracella, Eleonora Coratti, Lilia Cinti, Piergiorgio Roberto, Laura Petrarca and 8 more

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Article in Virus evolution, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Greta RomanoMicrobiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, V.le Golgi 19, 27100 Pavia, Italy.ORCID https://orcid.org/0000-0002-9076-8501
Roberta CampagnaMicrobiology and Virology Laboratory, Department of Molecular Medicine, Sapienza University, V.le Porta Tiburtina 28, 00185 Rome, Italy.
Guglielmo FerrariMicrobiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, V.le Golgi 19, 27100 Pavia, Italy.ORCID https://orcid.org/0000-0003-1478-6094
Antonino Maria Guglielmo PitroloMicrobiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, V.le Golgi 19, 27100 Pavia, Italy.
Ombretta TurrizianiMicrobiology and Virology Laboratory, Department of Molecular Medicine, Sapienza University, V.le Porta Tiburtina 28, 00185 Rome, Italy.
Matteo FracellaMicrobiology and Virology Laboratory, Department of Molecular Medicine, Sapienza University, V.le Porta Tiburtina 28, 00185 Rome, Italy.ORCID https://orcid.org/0000-0002-2885-2382
Eleonora CorattiMicrobiology and Virology Laboratory, Department of Molecular Medicine, Sapienza University, V.le Porta Tiburtina 28, 00185 Rome, Italy.
Lilia CintiMicrobiology and Virology Laboratory, Department of Molecular Medicine, Sapienza University, V.le Porta Tiburtina 28, 00185 Rome, Italy.
Piergiorgio RobertoMicrobiology and Virology Laboratory, Department of Molecular Medicine, Sapienza University, V.le Porta Tiburtina 28, 00185 Rome, Italy.
Laura PetrarcaDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, viale Regina Elena 324, 00161 Rome, Italy.
Raffaella NennaDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, viale Regina Elena 324, 00161 Rome, Italy.
Fabio MidullaDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, viale Regina Elena 324, 00161 Rome, Italy.
Alice Bonetti
Amelia LicariPediatric Clinic, Fondazione IRCCS Policlinico San Matteo, V.le Golgi 19, Pavia 27100, Italy.
Antonio PirallaMicrobiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, V.le Golgi 19, 27100 Pavia, Italy.ORCID https://orcid.org/0000-0002-6062-2579
Guido AntonelliMicrobiology and Virology Laboratory, Department of Molecular Medicine, Sapienza University, V.le Porta Tiburtina 28, 00185 Rome, Italy.ORCID https://orcid.org/0000-0002-2533-2939
Fausto BaldantiMicrobiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, V.le Golgi 19, 27100 Pavia, Italy.ORCID https://orcid.org/0000-0001-6559-8099
Alessandra PierangeliDepartment of Wellbeing, Health and Environmental Sustainability, Sapienza University, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID https://orcid.org/0000-0003-0633-360X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) remains a leading cause of hospitalization despite the recent implementation of infant immunoprophylaxis programs. The inter- and intrahost levels of genetic variation across the genome have not been extensively investigated. Hence, the aim of this study was to characterize the whole genome of RSV strains circulating within two Italian areas during the 2024-5 RSV season, corresponding to the first season after implementation of the national nirsevimab prophylaxis program. Whole genome sequencing (WGS) was performed on 88 respiratory samples that tested positive for RSV. Clinical records showed that none of the sequenced patients had received nirsevimab prophylaxis. The WGS strains obtained in the present study were correlated with the RSV strains circulating in Europe using phylogenetic inference. A newly designed bioinformatic pipeline was developed to evaluate the extent of genetic variation within hosts and reveal the distribution of minority mutations among RSV lineages. RSV-A (

Indexed as

evolutionintrahost genetic diversityminority variantsrespiratory syncytial virusrespiratory viruses

Identifiers

PMID42592280
PMCPMC13464729

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.