Evidence map›Paper›PMID 42592555›Full record

ArticleJournal of family medicine and primary care2026

Varicella-zoster virus meningitis during amenamevir therapy with measured cerebrospinal fluid drug concentration: A case report.

Rina Matsumoto, Hiroshi Horiuchi, Tsuyoshi Otsuka, Hiroshi Miyazaki, Ryosuke Furuya

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of family medicine and primary care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rina MatsumotoDepartment of Critical Care and Emergency Medicine, National Hospital Organization Yokohama Medical Center, Yokohama City, Kanagawa, Japan.
Hiroshi HoriuchiDepartment of Critical Care and Emergency Medicine, National Hospital Organization Yokohama Medical Center, Yokohama City, Kanagawa, Japan.
Tsuyoshi OtsukaDepartment of Critical Care and Emergency Medicine, National Hospital Organization Yokohama Medical Center, Yokohama City, Kanagawa, Japan.
Hiroshi MiyazakiDepartment of Critical Care and Emergency Medicine, National Hospital Organization Yokohama Medical Center, Yokohama City, Kanagawa, Japan.
Ryosuke FuruyaDepartment of Critical Care and Emergency Medicine, National Hospital Organization Yokohama Medical Center, Yokohama City, Kanagawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Varicella-zoster virus (VZV) meningitis has been reported during treatment with amenamevir (AMNV). Although case reports have raised concerns about its ability to prevent central nervous system (CNS) complications, cerebrospinal fluid (CSF) penetration has not been evaluated. We report the first case of VZV meningitis with measured CSF AMNV concentration. An 80-year-old man developed altered consciousness and dysarthria on day 7 of AMNV therapy for thoracic herpes zoster. The CSF AMNV concentration on admission was 0.086 µmol/L (41.3 ng/mL), measured 20-24 h after the last dose, within the reported

Indexed as

Amenamevirantiviral agentscerebrospinal fluidpharmacokineticsvaricella-zoster virus meningitis

Identifiers

PMID42592555
PMCPMC13466070

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.