Evidence map›Paper›PMID 42592691›Full record

ArticleArchiv der Pharmazie2026

Design, Synthesis, and Biological Evaluation of Biphenylsulfonyl Indole-Based Thiosemicarbazones as Potential AChE and CA I-II Inhibitors.

Fatima Yaqoob, Nastaran Sadeghian, Feyzi Sinan Tokali, Parham Taslimi, Adel Qlayel Alkhedaide, Aiysha Althobaiti, Orhan Ulucay, Mohamed M Ibrahim, Magdi E A Zaki, Sobhi M Gomha and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archiv der Pharmazie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Fatima YaqoobInstitute of Chemical Sciences, Bahauddin Zakariya University, Multan, Pakistan.
Nastaran SadeghianDepartment of Biotechnology, Faculty of Science, Bartin University, Bartin, Türkiye.ORCID https://orcid.org/0009-0004-2966-9231
Feyzi Sinan TokaliDepartment of Material and Material Processing Technologies, Kars Vocational School, Kafkas University, Kars, Türkiye.ORCID https://orcid.org/0000-0001-5532-8802
Parham TaslimiDepartment of Biotechnology, Faculty of Science, Bartin University, Bartin, Türkiye.ORCID https://orcid.org/0000-0002-3171-0633
Adel Qlayel AlkhedaideDepartment of Clinical Laboratory Sciences, Turabah University College, Taif University, Taif, Saudi Arabia.
Aiysha AlthobaitiDepartment of Biochemistry, College of Medicine, Taif University, Taif, Saudi Arabia.
Orhan UlucayDepartment of Bioengineering, Faculty of Engineering and Architecture, Kafkas University, Kars, Türkiye.ORCID https://orcid.org/0000-0002-0820-5372
Mohamed M IbrahimDepartment of Chemistry, Faculty of Science, Kafrelsheikh University, Kafr El-Sheikh, Egypt.ORCID https://orcid.org/0000-0002-4351-009X
Magdi E A ZakiDepartment of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0002-5643-9202
Sobhi M GomhaDepartment of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, Saudi Arabia.ORCID https://orcid.org/0000-0002-7739-2837
Xianliang ZhaoSchool of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, Zhejiang Province, China.ORCID https://orcid.org/0000-0002-7996-7075
Halil ŞenolFaculty of Pharmacy, Department of Pharmaceutical Chemistry, Bezmialem Vakif University, Fatih, İstanbul, Türkiye.ORCID https://orcid.org/0000-0002-8333-035X
Muhammad Usman JanjuaInternational Medicine Institute, Changsha Medical University, Changsha, China.
Zahid ShafiqInstitute of Chemical Sciences, Bahauddin Zakariya University, Multan, Pakistan.ORCID https://orcid.org/0000-0003-4088-8297

Funding

Deanship of Graduate Studies and Scientific ResearchTaif University
6 · The paper itself

Abstract

In this study, 20 novel biphenyl-sulfonamide-indole-based thiosemicarbazone derivatives (1-20) were synthesized and evaluated for their inhibitory activities against AChE, hCA I, and hCA II. Among the synthesized compounds, compound 20 (4-nitrophenyl substituted) exhibited the highest inhibitory activity against all three enzymes (AChE K

Indexed as

Biphenyl CompoundsCarbonic Anhydrase ICarbonic Anhydrase IICarbonic Anhydrase InhibitorsCholinesterase InhibitorsDrug DesignIndolesThiosemicarbazonesAcetylcholinesteraseAnimalsHumansMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureStructure-Activity RelationshipAcetylcholinesteraseBiphenyl CompoundsCarbonic Anhydrase ICarbonic Anhydrase IICarbonic Anhydrase InhibitorsCholinesterase InhibitorsIndolesThiosemicarbazonesAChEAlzheimerCA I‐IIMD simulationsthiosemicarbazone

Identifiers

PMID42592691
PMCPMC13470467

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.