Evidence map›Paper›PMID 42593434›Full record

ArticleAndrology2026

Live Birth Rates After Varicocele Embolization in Patients After Failed In Vitro Fertilization With Intracytoplasmic Sperm Injection.

Anthony Verstandig, Adam Farkas

Abstract read
In one paragraph

Article in Andrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

2 authors.

Anthony VerstandigInterventional Radiology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.ORCID https://orcid.org/0000-0001-6233-3140
Adam FarkasInterventional Radiology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.ORCID https://orcid.org/0000-0002-1294-9374

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesWhile in vitro fertilization with intracytoplasmic sperm injection (IVF-ICSI) bypasses abnormalities in sperm concentration, motility, and morphology, it still has a significant failure rate. We report our experience on the effect of varicocele embolization (VE) on couples with varicocele related primary male factor infertility in whom IVF/ICSI failed to result in a live birth (LB). MATERIAL AND

methodsThis single center retrospective cohort study documents 42 couples who had failed to have a LB after single or multiple IVF/ICSI cycles and in whom the male partner subsequently had left or bilateral varicoceles treated by transcatheter embolization. Other inclusion criteria were maternal age of 35 or less at the time of VE and at least 24 months follow up after embolization. The end point was LB by natural conception or by IVF-ICSI. Pre-procedure data was documented at the time of referral for varicocele embolization. Images of the procedures were reviewed, and post VE data was collected by telephone questionnaire from one of the partners.

resultsPrior to varicocele embolization, the 42 couples had undergone 151 oocyte retrievals (median 2, range 1-21) and 200 embryo transfers (median 3, range 1-26) with no LB. During a median follow up period of 54 months (range 25-111) following VE, there were 60 LB (65 children) amongst 36 of the 42 couples (86%). Thirty-four couples underwent a total of 119 oocyte retrievals and 149 embryo transfer procedures with 28 achieving 36 LB (41 children). Fifteen couples had 23 LB (23 children) from natural conceptions. One couple had an LB after intrauterine insemination.

conclusionVE in this challenging patient population may treat varicocele associated sperm function problems not addressed by ICSI and could be beneficial before assisted reproductive techniques in varicocele related male factor infertility.

Indexed as

Birth RateEmbolization, TherapeuticInfertility, MaleLive BirthSperm Injections, IntracytoplasmicVaricoceleAdultFemaleFertilization in VitroHumansMalePregnancyRetrospective StudiesTreatment Failureassisted reproductive techniquesintracytoplasmic sperm injectionin vitro fertilizationmale factor infertilityvaricocele embolizationvaricocele repair

Identifiers

PMID42593434
PMCPMC13592059

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.