Evidence map›Paper›PMID 42593849›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

MetaboSense: An Integrated Quantum Dot-Mediated Aptamer Assay and Modular Microfluidic Platform for Continuous In-Line Monitoring of Lung Metabolism During Ex Vivo Perfusion.

Sanjana Srikant, Pouyan Keshavarz Motamed, Thomas Borrillo, Lielle Ronen, Gabriel Siebiger, Guillermo Garza, Hesam Abouali, Md Fahim Al Fattah, Ines Jaber, Dayan Ban and 5 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sanjana SrikantDepartment of Electrical and Computer Engineering, University of Waterloo, Waterloo, Ontario, Canada.
Pouyan Keshavarz MotamedDepartment of Electrical and Computer Engineering, University of Waterloo, Waterloo, Ontario, Canada.ORCID https://orcid.org/0009-0005-0286-2848
Thomas BorrilloLatner Thoracic Research Laboratories, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
Lielle RonenLatner Thoracic Research Laboratories, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.ORCID https://orcid.org/0009-0005-7194-2163
Gabriel SiebigerLatner Thoracic Research Laboratories, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0001-8027-6741
Guillermo GarzaLatner Thoracic Research Laboratories, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
Hesam AboualiDepartment of Electrical and Computer Engineering, University of Waterloo, Waterloo, Ontario, Canada.ORCID https://orcid.org/0009-0003-0810-2730
Md Fahim Al FattahDepartment of Electrical and Computer Engineering, University of Waterloo, Waterloo, Ontario, Canada.
Ines JaberLatner Thoracic Research Laboratories, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
Dayan BanDepartment of Electrical and Computer Engineering, University of Waterloo, Waterloo, Ontario, Canada.ORCID https://orcid.org/0000-0002-5271-3163
Marcelo CypelLatner Thoracic Research Laboratories, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
Mingyao LiuLatner Thoracic Research Laboratories, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-9188-8417
Shaf KeshavjeeLatner Thoracic Research Laboratories, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
Andrew T SageLatner Thoracic Research Laboratories, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0003-2517-9062
Mahla PoudinehDepartment of Electrical and Computer Engineering, University of Waterloo, Waterloo, Ontario, Canada.ORCID https://orcid.org/0000-0001-8684-3102

Funding

CIHR
6 · The paper itself

Abstract

Organ transplantation provides a life-saving intervention for patients with end-stage lung disease; however, access to this treatment remains limited by the shortage of donor organs. Ex vivo lung perfusion (EVLP) is a platform that enables surgeons to assess extended-criteria for donor lungs prior to transplantation and has safely expanded the donor pool. Yet current EVLP biochemical assessments rely on intermittent manual sampling and fail to capture dynamic metabolic changes. Here we present MetaboSense, a first-of-its-kind microfluidic platform for continuous, real-time, multiplexed monitoring of glucose and lactate-key metabolites that report on donor lung metabolism-during EVLP. The system integrates a bead-based, quantum dot-mediated aptamer assay with modular microfluidics for in-line biomarker measurement. MetaboSense achieves limits of detection of 0.74 mM (glucose) and 1.19 mM (lactate) with analytical precision (R

Indexed as

continuous monitoringex vivo lung perfusionglucosein‐line measurementlactatemetabolites

Identifiers

PMID42593849
PMCPMC13472114

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.