Evidence map›Paper›PMID 42594045›Full record

ArticleKidney & blood pressure research2026

Nutritional Status as Predictor for Mortality in Older Adults with Acute Kidney Injury.

María G Zavala-Cerna, Alma L Guzmán-Gurrola, Gabriela Asencio-Del Real, José A Novoa-Burquez, Julio A Díaz-Ramos, Gerardo Oliva-Armas, David Leal-Mora, Evelyn Yared Villanueva-Muñoz, Andrea Alejandra Sánchez-Soto, Urima Alejandra Castañeda-Lara and 2 more

Abstract read
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Article in Kidney & blood pressure research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

María G Zavala-CernaUniversidad Autónoma de Guadalajara, Guadalajara, Mexico.
Alma L Guzmán-GurrolaHigh Specialty Geriatric Care Unit, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico.
Gabriela Asencio-Del RealHigh Specialty Geriatric Care Unit, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico.
José A Novoa-BurquezInstituto de Seguridad y Servicios Sociales de los Trabajadores del Gobierno y Municipios del Estado de Baja California ISSSTECALI "El mirador,", Tijuana, Mexico.
Julio A Díaz-RamosHigh Specialty Geriatric Care Unit, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico.
Gerardo Oliva-ArmasHigh Specialty Geriatric Care Unit, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico.
David Leal-MoraHigh Specialty Geriatric Care Unit, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico.
Evelyn Yared Villanueva-MuñozHigh Specialty Geriatric Care Unit, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico.
Andrea Alejandra Sánchez-SotoUniversity of Guadalajara Health Sciences Center, Guadalajara, Mexico.
Urima Alejandra Castañeda-LaraTonalá Center, University of Guadalajara, Guadalajara, Mexico.
Aranza Gabriela Montoya-GonzálezTonalá Center, University of Guadalajara, Guadalajara, Mexico.
Jonathan S Chávez-IñiguezUniversity of Guadalajara Health Sciences Center, Guadalajara, Mexico, jonarchi_10@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOlder adults (OAs) exhibit the highest incidence of acute kidney injury (AKI), with outcomes influenced by comorbidities, frailty, and malnutrition. Nutritional status, a potentially modifiable factor, has not been extensively evaluated as a mortality predictor in hospitalized OA with AKI. Our purpose was to report on the mortality risk provided by the nutritional status, comorbidities, and biochemical parameters in OA with AKI.

methodsIn this prospective cohort study (July 2024-July 2025) conducted at a tertiary geriatric unit, hospitalized OA with AKI, diagnosed according to KDIGO criteria, underwent a comprehensive nutritional assessment within 48 h of admission. The Geriatric Nutritional Risk Index (GNRI), Mini Nutritional Assessment, anthropometric measurements, and biochemical markers were recorded. The primary outcome was in-hospital all-cause mortality; secondary outcomes included the analysis of all-cause mortality according to nutritional and clinical factors, such as dysphagia, hyporexia, and GNRI quartiles (Q1-Q4). Logistic regression models were used to identify independent predictors of mortality, and all models were adjusted for AKI severity.

resultsOf 742 admissions, 187 patients met the inclusion criteria. The median age was 76.8 years, and 50% were male. GNRI quartile analysis demonstrated a progressive deterioration in anthropometric and biochemical markers from Q4 to Q1. Mortality was higher in the high-risk GNRI group (42.2% vs. 30.1%); however, this difference did not reach statistical significance (p = 0.098). In adjusted analyses, dysphagia (adjusted odds ratio [aOR] 6.11; 95% CI: 1.82-20.51; p = 0.003), hyporexia (aOR 2.24; 95% CI: 1.02-4.92; p = 0.044), and lower GNRI (aOR 1.07 per unit decrease; 95% CI: 1.02-1.13; p = 0.004) were independently associated with increased mortality. In contrast, a higher mid-upper arm circumference was independently associated with a protective effect (aOR 0.78; 95% CI: 0.67-0.91; p = 0.001).

conclusionsIn OA hospitalized with AKI, poor nutritional status, particularly dysphagia, hyporexia, and lower GNRI, was independently associated with increased in-hospital mortality, whereas preserved muscle mass was protective. Early, simple, bedside nutritional assessments may help guide targeted interventions to improve outcomes in this high-risk population.

Indexed as

Acute Kidney InjuryNutritional StatusAgedAged, 80 and overFemaleHumansMaleMalnutritionNutrition AssessmentProspective StudiesAcute kidney injuryKidney replacement therapyMalnutritionNutritional statusOlder adults

Identifiers

PMID42594045
PMCPMC13608887

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.