Evidence map›Paper›PMID 42594078›Full record

ArticlePLoS medicine2026

Socioeconomic inequalities in functional ageing trajectories in England and Canada: A comparative longitudinal cohort study.

Stephanie Schrempft, Shelby Vereecke, Mayssam Nehme, Kim L Schmidt, Idris Guessous, Michael S Kobor, Paola Zaninotto, Silvia Stringhini

Abstract readComparative Study
In one paragraph

Article in PLoS medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Stephanie SchrempftDivision of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.ORCID https://orcid.org/0000-0001-7871-364X
Shelby VereeckeSchool of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0009-0004-5138-6414
Mayssam NehmeDivision of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.ORCID https://orcid.org/0000-0001-9189-6495
Kim L SchmidtEdwin S.H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Idris GuessousDivision of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.
Michael S KoborEdwin S.H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0003-4140-1743
Paola ZaninottoDepartment of Epidemiology and Public Health, University College London, London, United Kingdom.ORCID https://orcid.org/0000-0003-3036-0499
Silvia StringhiniDivision of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.ORCID https://orcid.org/0000-0002-4387-8943

Funding

Project-001R01AG017644 · NIA · UNIVERSITY OF LONDON INST OF NEUROLOGY · PI Andrew Steptoe · 2000 to 2026
$56.2M
NIA NIH HHS R01 AG017644
6 · The paper itself

Abstract

backgroundCross-country comparisons can provide valuable insights into the societal and policy contexts that shape socioeconomic inequalities in ageing. However, longitudinal comparative research in this area is scarce. We therefore examined associations between socioeconomic conditions and functional ageing trajectories in a longitudinal comparison between England and Canada. METHODS AND

findingsIn this longitudinal cohort study, data were drawn from the English Longitudinal Study of Ageing (ELSA, 2012-2023, N = 8511, 55% women, aged 50-85 years at baseline) and the Canadian Longitudinal Study on Aging (CLSA, 2012-2021, N = 22,605, 49% women, aged 50-85 years at baseline). Associations between total household wealth and physical functioning (gait speed, grip strength, chair stands, lung function, self-rated hearing, self-rated eyesight, mobility difficulties, and difficulties performing activities of daily living) were examined within each cohort using mixed-effects models, with additional adjustment for chronic conditions, weight status, health behaviours, and social connections. In each cohort, less wealth was associated with a poorer level of functioning across outcomes, and a greater decline in mobility and the ability to perform activities of daily living with age. In ELSA, wealthier individuals experienced a steeper decline in gait speed compared to their less wealthy counterparts, although their level remained higher throughout the follow-up period. In CLSA, wealthier individuals had a steeper decline in chair rise performance and self-rated eyesight compared to less wealthy individuals. Wealth inequalities in the level of functioning were generally greater in ELSA than in CLSA, especially for gait speed (years of functioning lost at age 60 = 15, 95% CI [12.2, 17.8] versus 9, 95% CI [8.6, 9.4]) and difficulties with basic activities of daily living (20, 95% CI [19.5, 20.4] versus 9, 95% CI [8.6, 9.4]). There were some significant wealth by sex interaction effects, such that women with the least wealth had more difficulties with mobility, activities of daily living, and hearing than men with the least wealth, but better lung function. Associations between wealth and functional outcomes were attenuated but persisted after adjustment for chronic conditions, weight status, health behaviours, and social connections. Limitations include the focus on socioeconomic conditions in adulthood and the inability to examine the contribution of other important factors to the observed associations, such as access to private healthcare.

conclusionsSocioeconomic inequalities in functional ageing are apparent in England and Canada, are larger in England than in Canada, and are not fully explained by common risk factors. These findings suggest that multilevel approaches, combining individual-level interventions with structural measures, are required to address socioeconomic inequalities and cross-country differences in functional ageing. Variation in wealth associations by sex suggests that approaches to reducing socioeconomic inequalities in functional health should account for potential sex differences.

Indexed as

AgingSocioeconomic FactorsActivities of Daily LivingAgedAged, 80 and overCanadaCanadian Longitudinal Study on AgingEnglandFemaleHumansLongitudinal StudiesMaleMiddle AgedSocioeconomic Disparities in Health

Identifiers

PMID42594078
PMCPMC13472442

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.