Evidence map›Paper›PMID 42595368›Full record

Trial reportBMJ open2026

Protocol for a randomised, double-blind, placebo-controlled clinical trial on the effects of high-dose vitamin B multivitamin supplementation with and without

Chai Hong Yeong, Yin How Wong, Su Yin Lim, Bee Kim Tan, Selvaraja Seerangam, Karuthan Chinna, Norlisah Ramli, Kartini Rahmat, Ouzreiah Nawawi, Li Kuo Tan and 3 more

Abstract readRandomized Controlled TrialClinical Trial, Phase IIClinical Trial, Phase I
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chai Hong YeongSchool of Medicine, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia chaihong.yeong@taylors.edu.my.ORCID http://orcid.org/0000-0003-1572-4143
Yin How WongSchool of Medicine, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia.
Su Yin LimSchool of Medicine, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia.
Bee Kim TanDigital Health and Medical Advancement Impact Lab, Taylor's University, Subang Jaya, Malaysia.
Selvaraja SeerangamDigital Health and Medical Advancement Impact Lab, Taylor's University, Subang Jaya, Malaysia.
Karuthan ChinnaInstitute for Research, Development and Innovation, IMU University, Kuala Lumpur, Malaysia.ORCID http://orcid.org/0000-0002-2035-344X
Norlisah RamliDepartment of Biomedical Imaging, University of Malaya, Federal Territory of Kuala Lumpur, Malaysia.
Kartini RahmatDepartment of Biomedical Imaging, University of Malaya, Federal Territory of Kuala Lumpur, Malaysia.
Ouzreiah NawawiDepartment of Biomedical Imaging, University of Malaya, Federal Territory of Kuala Lumpur, Malaysia.
Li Kuo TanDepartment of Biomedical Imaging, University of Malaya, Federal Territory of Kuala Lumpur, Malaysia.
Azlan Che AhmadDepartment of Biomedical Imaging, University of Malaya, Federal Territory of Kuala Lumpur, Malaysia.
Vladimir StajicExecutive Brain Mastery, Sydney, New South Wales, Australia.
Jew Puay TayBlackmores Institute, Warriewood, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionB-vitamins and herbal supplements such as METHODS AND ANALYSIS: This is a phase I/II, randomised, double-blind, placebo-controlled clinical trial involving 108 healthy adults aged 30-55 years, allocated to three groups: (A) high-dose vitamin B multivitamin supplementation with ETHICS AND DISSEMINATION: Ethics approval was granted by the Medical Research Ethics Committee, Ministry of Health Malaysia (NMRR-19-379-46101 (ISR); Protocol Number: Exec B). Results will be disseminated through peer-reviewed publications and scientific conferences. TRIAL REGISTRATION NUMBER: ACTRN12622001150730.

Indexed as

BrainDietary SupplementsPassifloraVitamin B ComplexAdultBiomarkersCognitionDouble-Blind MethodFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedResearch DesignBiomarkersVitamin B ComplexBrainClinical TrialCognitionFunctional Magnetic Resonance ImagingMENTAL HEALTH

Identifiers

PMID42595368
PMCPMC13475457

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.