Evidence map›Paper›PMID 42595808›Full record

ReviewNature biomedical engineering2026

A practical toolbox for modelling fibrosis in vitro.

Margaretha A J Morsink, Sharon Fleischer, Trevor R Nash, Thomas Falcucci, Julie Leonard-Duke, Vanessa Li, Meghan Pinezich, Jugal Kishore Sahoo, Onur Hasturk, Andy Lee and 6 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Margaretha A J Morsink *Department of Biomedical Engineering, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0001-5511-6105
Sharon Fleischer *Department of Biomedical Engineering, Columbia University, New York, NY, USA.
Trevor R Nash *Department of Biomedical Engineering, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0003-4555-7577
Thomas Falcucci *Department of Biomedical Engineering, Tufts University, Medford, MA, USA.
Julie Leonard-DukeDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Vanessa LiDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-5183-7930
Meghan PinezichDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Jugal Kishore SahooDepartment of Biomedical Engineering, Tufts University, Medford, MA, USA.ORCID http://orcid.org/0000-0003-2503-9115
Onur HasturkDepartment of Biomedical Engineering, Tufts University, Medford, MA, USA.
Andy LeeDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Sophia TheodossiouDepartment of Biomedical Engineering, Tufts University, Medford, MA, USA.
Jaewon ChoiDepartment of Biomedical Engineering, Tufts University, Medford, MA, USA.
Pamela GraneyDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0003-0428-2634
Clark HungDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
David L KaplanDepartment of Biomedical Engineering, Tufts University, Medford, MA, USA. david.kaplan@tufts.edu.ORCID http://orcid.org/0000-0002-9245-7774
Gordana Vunjak-NovakovicDepartment of Biomedical Engineering, Columbia University, New York, NY, USA. gv2131@columbia.edu.ORCID http://orcid.org/0000-0002-9382-1574

Funding

Tissue Engineering Resource Center: TTDP41EB027062 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gordana Vunjak-Novakovic · 2019 to 2026
$12.6M
Cystic Fibrosis Foundation (CF Foundation) VUNJAK23XX0U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) 5R01HL076485-15U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) P41 EB027062
6 · The paper itself

Abstract

Fibrosis is a widespread disease implicated in millions of deaths worldwide and impacting diverse organs, including the heart, lung, kidney, liver and synovium. Characterized by excessive extracellular matrix deposition, fibrosis leads to tissue scarring and dysfunction, ultimately resulting in organ failure. The development of faithful experimental models of fibrosis is challenged by its complexity, limiting the discovery of effective therapeutics. Human in vitro tissue models are emerging as powerful systems that capture the pathophysiology of fibrosis to uncover disease mechanisms, identify biomarkers and facilitate drug discovery. Here we define the hallmarks of fibrosis across organ systems to establish foundational design criteria necessary for modelling human fibrosis in vitro. We provide an overview of state-of-the-art technologies and recent advancements in tissue fibrosis models pointing towards potential future directions. Finally, we offer a practical toolkit for researchers with diverse expertise to implement these considerations into future tissue models.

Identifiers

PMID42595808

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.