Evidence map›Paper›PMID 42595885›Full record

ArticleNature human behaviour2026

Distinct neural processes link speech planning and execution.

Suseendrakumar Duraivel, Shervin Rahimpour, Katrina Barth, Chia-Han Chiang, Charles Wang, Stephen C Harward, Shivanand P Lad, Daniel P Sexton, Allan H Friedman, Saurabh R Sinha and 4 more

Abstract read
In one paragraph

Article in Nature human behaviour, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Premotor cortex uses a compositional neural geometry to plan words.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Suseendrakumar DuraivelDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Shervin RahimpourDepartment of Neurosurgery, Duke School of Medicine, Durham, NC, USA.
Katrina BarthDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Chia-Han ChiangDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Charles WangDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Stephen C HarwardDepartment of Neurosurgery, Duke School of Medicine, Durham, NC, USA.
Shivanand P LadDepartment of Neurosurgery, Duke School of Medicine, Durham, NC, USA.
Daniel P SextonDepartment of Neurosurgery, Duke School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0002-0403-2574
Allan H FriedmanDepartment of Neurosurgery, Duke School of Medicine, Durham, NC, USA.
Saurabh R SinhaPenn Epilepsy Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Gregory HickokDepartment of Cognitive Sciences, University of California, Irvine, CA, USA.
Derek G SouthwellDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Jonathan ViventiDepartment of Biomedical Engineering, Duke University, Durham, NC, USA. j.viventi@duke.edu.ORCID http://orcid.org/0000-0001-6054-0541
Gregory CoganDepartment of Biomedical Engineering, Duke University, Durham, NC, USA. gregory.cogan@duke.edu.ORCID http://orcid.org/0000-0003-1557-6507

Funding

Advancing Epilepsy Diagnosis with Flexible, High-Resolution Thin-Film ElectrodesUG3NS120172 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BHANDARI, RAJMOHAN, FRIEDMAN, DANIEL · 2022 to 2025
$4.6M
A Wireless micro-ECoG Prosthesis for SpeechR01DC019498 · NIDCD · DUKE UNIVERSITY · PI SHEPARD, KENNETH L, SOLZBACHER, FLORIAN · 2021 to 2025
$3.1M
The overlap of speech production and verbal working memoryR01NS129703 · NINDS · DUKE UNIVERSITY · PI Gregory B Cogan · 2023 to 2026
$1.8M
National Science Foundation (NSF) DGE-1644868NIDCD NIH HHS R01 DC019498NINDS NIH HHS R01 NS129703NINDS NIH HHS UG3 NS120172United States Department of Defense | United States Army | Army Medical Command | Congressionally Directed Medical Research Programs (CDMRP) W81XWH-21-0538U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS129703U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) UG3NS120172U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) R01DC019498
6 · The paper itself

Abstract

Speaking is the primary way that humans communicate. This communication is enabled by a production system that can plan and execute unique combinations of speech sounds. Although a distributed network of brain regions has been implicated in speaking, it is unclear how planning and execution of speech are coordinated to produce meaningful sounds. Leveraging the high spatio-temporal resolution of intracranial recordings at different spatial scales, we show distinct neural mechanisms that facilitate speech planning and execution. During planning, different levels of speech units are coded discretely at distinct prefrontal sites. These planned units are then dynamically integrated at various cortical levels to guide subsequent execution. During speech execution, speech motor regions generate continuous sequences that reflect both discrete speech sound units and their transitional properties between units. This rapid neural transition from discrete speech units to motor sequences links speech planning with execution and enables our effortless ability to speak.

Identifiers

PMID42595885
PMCPMC13599607

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.