Evidence map›Paper›PMID 42596096›Full record

ArticleAmerican journal of physiology. Cell physiology2026

Lipin1 restores nNOS sarcolemmal localization and improves fatigue resistance in Duchenne muscular dystrophy.

Ayat Azzam, Abdulrahman Jama, John Karanja Kamau, Lixin Dong, Brooklyn Morris, Pooneh Hajmirza Mohammadi Kamalabadi, Denish Maharjan, Abdullah A Alshudukhi, Hongmei Ren

Abstract read
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In one paragraph

Article in American journal of physiology. Cell physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Ayat AzzamDepartment of Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio, United States.
Abdulrahman JamaDepartment of Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio, United States.
John Karanja KamauDepartment of Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio, United States.ORCID 0009-0007-2985-4842
Lixin DongMumetel LLC, University Technology Park at IIT, Chicago, Illinois, United States.
Brooklyn MorrisDepartment of Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio, United States.
Pooneh Hajmirza Mohammadi KamalabadiDepartment of Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio, United States.
Denish MaharjanDepartment of Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio, United States.
Abdullah A AlshudukhiDepartment of Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio, United States.
Hongmei RenDepartment of Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio, United States.ORCID 0000-0003-0210-1502

Funding

The Role of Lipin1 in Myofiber Stability and IntegrityR01AR077574 · NIAMS · WRIGHT STATE UNIVERSITY · PI REN, HONGMEI · 2021 to 2025
$1.8M
DOD | MHS | Congressionally Directed Medical Research Programs (CDMRP) W81XWH2110679HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) 5R01 AR077574NIAMS NIH HHS R01 AR077574
6 · The paper itself

Abstract

In Duchenne muscular dystrophy (DMD), neuronal nitric oxide synthase (nNOS) is mislocalized from the sarcolemmal membrane and exhibits reduced expression and activity, impairing vasomodulation and contributing to increased muscle fatigue. Identification of upstream regulators that restore nNOS localization and function may provide therapeutic strategies to improve muscle performance in dystrophic muscle. In this study, we investigated the role of lipin1 in regulating nNOS expression, sarcolemmal localization, and nitric oxide synthase (NOS) activity in skeletal muscle. Lipin1 deficiency significantly reduced nNOS expression and total NOS enzymatic activity, whereas lipin1 overexpression enhanced these parameters. Skeletal muscle-specific lipin1 knockout mice (lipin1

Indexed as

Muscle FatigueMuscle, SkeletalMuscular Dystrophy, DuchenneNitric Oxide Synthase Type IPhosphatidate PhosphataseSarcolemmaAnimalsHumansMaleMiceMice, Inbred mdxMice, KnockoutLpin1 protein, mouseNitric Oxide Synthase Type INos1 protein, mousePhosphatidate PhosphataseDuchenne muscular dystrophydystrophinlipin1muscle fatiguenNOS

Identifiers

PMID42596096
PMCPMC13531045

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.