Evidence map›Paper›PMID 42596852›Full record

ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2026

Cord blood DNA methylation as a potential mediator in the association between prenatal ambient air pollution and early infant allergic symptoms in a Shanghai birth cohort.

Xiaoqin Chen, Junyang Li, Sijie Yang, Wenjun He, Jing Wu, Xiaohua Liu, Jing Li, Youjin Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cord blood DNA methylation as a potential mediator in the association between prenatal ambient air pollution and early infant allergic symptoms in a Shanghai birth cohort.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaoqin ChenDepartment of Otolaryngology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Junyang LiDepartment of Otolaryngology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Sijie YangDepartment of Otolaryngology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Wenjun HeDepartment of Otolaryngology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jing WuPediatric Translational Medicine Institute, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Xiaohua LiuDepartment of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Tongji University, Shanghai, China.
Jing LiDepartment of Neonatology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Youjin LiDepartment of Otolaryngology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0000-0001-9898-6274

Funding

Jin Coconut Seed Project JYZZ2024-FY-02Joint Program on Health Science & Technology Innovation of Hainan Province WSJK2025ZD212National Natural Science Foundation of China 82570045Sanya Science and Technology Special Fund 2024JFX038Science and Technology Development Fund of Shanghai Pudong New Area PKJ2024-Y16
6 · The paper itself

Abstract

backgroundPrenatal exposure to ambient air pollution has been associated with early-life allergic outcomes; however, underlying biological mechanisms remain incompletely understood.

methodsA total of 101 mother-infant pairs were ultimately included in this prospective birth cohort study. Maternal exposure to ambient air pollutants was assigned to geocoded residential addresses using spatiotemporal models. Allergic symptoms were defined as cumulative caregiver-reported symptoms occurring from birth to 6 months and assessed at the 6-month follow-up. DNA methylation in naïve CD4

resultsHigher first-trimester exposure to PM

conclusionsPrenatal ambient air pollution exposure was associated with early-life allergic symptoms, and cord blood DNA methylation at the PRKACB locus may represent a potential molecular mechanism underlying these associations. These findings are exploratory and require confirmation in larger studies.

Indexed as

Air PollutionDNA MethylationFetal BloodHypersensitivityMaternal ExposurePrenatal Exposure Delayed EffectsAdultAir PollutantsBirth CohortChinaDevelopmental Origins of Health and DiseaseFemaleHumansInfantInfant, NewbornMaleAir PollutantsParticulate Mattercord bloodDNA methylationearly‐life allergic symptomsmediation analysisnaïve CD4+ T cellsPM2.5 chemical componentsprenatal ambient air pollution exposure

Identifiers

PMID42596852
PMCPMC13473986

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.