ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
A Panel of Circulating Exosomal sncRNAs Associated With Lung Cancer Risk up to 10 Years in Advance.
Zhuokun Feng, Masaki Nasu, Ayman Abdul-Ghani, Yu Chen, Shaoqiu Chen, Isam Mohd Ibrahim, Hanqiu Zhang, Lauren Higa, Zitong Gao, Hua Yang and 3 more
Abstract read
In one paragraphArticle in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
13 authors.
Masaki NasuDepartment of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Ayman Abdul-GhaniPali Momi Medical Center, Honolulu, Hawaii, USA.
Isam Mohd IbrahimDepartment of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Hanqiu ZhangDepartment of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Lauren HigaDepartment of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Raphael BuenoDivision of Thoracic Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Loïc Le MarchandCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Funding
AIM-AHEAD Coordinating Center - All Four CoresOT2OD032581 · OD · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI Paul Avillach, Bettina M. Beech · 2021 to 2026
$168.7MUH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Peter R Hoffmann · 2012 to 2026
$60.3MThe Role of gp120 on Cardiovascular Disease in People Living with HIVU54MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI Lee Ellen Buenconsejo-Lum, Jerris Robert Hedges · 2017 to 2026
$59.5MUniversity of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI JOHN Alan SHEPHERD · 1996 to 2026
$56.2MUnderstanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4MTracking and Evaluation CoreU54GM138062 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI OKAMOTO, SCOTT KIYOSHI · 2021 to 2025
$15.5MSelenium Metabolism in the Heart: Impact of High Fructose and Low SeleniumP20GM139753 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Marla J Berry · 2022 to 2026
$13.3MPacific Center for Genome ResearchU54HG013243 · NHGRI · UNIVERSITY OF HAWAII AT MANOA · PI Alexandra Margaret Lynn Binder, Youping Deng · 2023 to 2026
$10.8MProject IV - Isolating placental effects of environmental toxicants in fetal development: AI/ML-augmented multi-omic causal discovery and prognostic modelingP20GM161995 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Yiqiang Zhang · 2026 to 2026
$5.3MGENES, DIET AND CARCINOGEN ACTIVATION IN SMOKERSR01CA085997 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI LE MARCHAND, LOIC · 2000 to 2004
$3.6MProfiling genome-wide circulating ncRNAs for the early detection of lung cancerR01CA223490 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI DENG, YOUPING · 2018 to 2022
$3.1MCirculating lipid and miRNA markers for early detection of breast cancer among women with abnormal mammogramsR01CA230514 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI DENG, YOUPING · 2019 to 2023
$2.8MNCI NIH HHS P30 CA071789NCI NIH HHS R01 CA085997NCI NIH HHS R01 CA223490NCI NIH HHS R01 CA230514NCI NIH HHS R01 CA316647NCI NIH HHS U01 CA164973NHGRI NIH HHS U54 HG013243NHGRI NIH HHS UE5 HG013826NIDDK NIH HHS T32 DK137523NIGMS NIH HHS P20 GM103466NIGMS NIH HHS P20 GM139753NIGMS NIH HHS P20 GM161995NIGMS NIH HHS U54 GM138062NIH HHS 1OT2OD032581-02NIH HHS 1OT2OD032581-02-PP90YNIH HHS 1R01CA316647NIH HHS 1UE5HG013826NIH HHS 3OT2OD032581-01S5-895NIH HHS OT2 OD032581NIH HHS P20GM103466NIH HHS P20GM139753NIH HHS P20GM161995NIH HHS P30CA071789NIH HHS R01CA223490NIH HHS R01CA230514NIH HHS R01CA85997NIH HHS T32DK137523NIH HHS U01CA164973NIH HHS U54GM138062NIH HHS U54HG013243NIH HHS U54MD007601NIMHD NIH HHS U54 MD007601
6 · The paper itselfAbstract
Current lung cancer screening fails to identify many individuals at risk beyond heavy smokers, highlighting the need for additional predictive biomarkers. This study profiles circulating exosomal small non-coding RNAs (sncRNAs) in a prospective cohort of 202 smokers, including 68 incident lung cancer cases with up to 16 years of follow-up. A structured 5 × 5 nested cross-validation framework incorporating feature selection, classifier comparison, and outer-loop evaluation identifies a panel of 31 sncRNA risk biomarkers. The optimized random forest model achieves an area under the curve (AUC) of 0.97 in outer-fold testing (sensitivity = 0.93; specificity = 1.00). The derived risk score remains independently associated with incident lung cancer after adjustment for demographic and smoking variables (odds ratio [OR] = 13.19, 95% confidence interval [CI] 6.83-25.45) and is associated with shorter time-to-diagnosis in competing risks analysis (subdistribution hazard ratio [sHR] = 4.78, 95% CI 3.57-6.41). Associations are observed up to 10 years prior to diagnosis. Target gene analysis implicates pathways relevant to lung tumorigenesis, including PI3K-Akt, p53, and MAPK signaling. These findings suggest that plasma exosomal sncRNAs may contribute to early lung cancer risk assessment and warrant further evaluation in independent pre-diagnostic cohorts.
Indexed as
exosomemachine learningplasmapre‐diagnosis biomarkersmall non‐coding RNA
Identifiers
PMID42596913
PMCPMC13474057
What Socratic holds
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