ArticlePregnancy (Hoboken, N.J.)2026
Low-frequency electroacupuncture attenuates insulin resistance in a rat model of diet-induced maternal obesity.
Article in Pregnancy (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Maternal obesity is highly prevalent worldwide, conferring elevated risks of maternal/fetal complications and adult-onset disease in offspring. Obesity and pregnancy are both states of insulin resistance. Percutaneous electrical stimulation of skeletal muscle, better known as electroacupuncture (EA), mitigates insulin resistance in polycystic ovarian syndrome and diabetes, but its efficacy in pregnancy is unknown. We aimed to determine if EA can attenuate insulin resistance in pregnant Wistar rats with high-fat, high-sucrose (HFS) diet-induced obesity. Methods: Nineteen HFS-exposed dams receiving 12-14 sessions of EA of rectus abdominis, tibialis anterior, soleus and gastrocnemius (3/15 Hz frequency, 10 mA intensity, 30 min) under isoflurane anesthesia (HFS+EA group) were compared with 19 untreated HFS-exposed dams receiving control anesthesia (HFS group) and 10 nonobese, nonpregnant controls (Ctrl group). On embryonic day (E)19 ± 1, insulin sensitivity was measured as the steady-state glucose infusion rate (GIR) during a gold-standard hyperinsulinemic-euglycemic clamp. Body composition, fasting blood glucose, fasting plasma insulin, serum corticosterone, blood pressure, pancreatic ß-cell mass and hepatic malonaldehyde/triglyceride content were determined. Results: Compared to the Ctrl group, the HFS group exhibited a decreased GIR (mean ± SEM = 13.3 ± 1.33 vs. 18.2 ± 1.37 mg/kg/min, Conclusion: EA attenuated insulin resistance in this rat model of maternal obesity. The effects of EA on fetoplacental growth and litter size require further investigation, especially given the latter observation could signal a potential safety issue.
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