ReviewAmerican journal of cancer research2026
Orthodontic treatment outcomes and safety for secondary dentofacial deformities after childhood cancer therapy: a systematic review and meta-analysis.
Review in American journal of cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo systematically evaluate the treatment outcomes and safety of orthodontic intervention for secondary dentofacial deformities after childhood cancer therapy, with particular emphasis on occlusal outcomes, oral health-related quality of life, treatment-related complications, and dental developmental abnormalities relevant to orthodontic management.
methodsA comprehensive search of PubMed, Embase, Cochrane Library, Web of Science, Scopus, and CINAHL was performed using terms related to cancer, orthodontic treatment, and treatment outcomes. Eligible studies included observational or comparative clinical studies reporting either treatment efficacy outcomes (e.g., w-PAR, ICON, and oral health-related quality of life) or treatment safety/sequelae outcomes (e.g., treatment-related complications and dental developmental abnormalities). Risk of bias was assessed using the Newcastle-Ottawa Scale. For efficacy outcomes, pooled standardized mean differences with 95% confidence intervals were calculated; for safety/sequelae outcomes, pooled risk ratios with 95% confidence intervals were estimated. Random-effects models were applied in Stata, and heterogeneity was assessed using Cochran's Q and the I
resultsTen studies published between 2001 and 2023 were included. For w-PAR, the pooled effect showed a significant overall change (SMD = -1.12, 95% CI -2.22 to -0.01; I
conclusionOrthodontic intervention in survivors of childhood cancer may be associated with improvements in occlusal outcomes and oral health-related quality of life; however, the evidence for treatment efficacy remains uncertain, largely due to substantial between-study heterogeneity. At the same time, survivors appear to have a significantly increased risk of treatment-related complications.
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Registered trials
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