Evidence map›Paper›PMID 42597234›Full record

ArticleAmerican journal of cancer research2026

Targeting FAM64A: a promising strategy to halt liver cancer angiogenesis and enhance immunity.

Liping Bai, Xueyan Yang, Lixian Bai, Zhongkun Ren, Hong Gong, Yinghui Zhang, Han Chen, Zhijian Ma

Abstract read
In one paragraph

Article in American journal of cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Liping BaiDepartment of Gastroenterology, The Affiliated Hospital of Yunnan University Kunming, Yunnan, China.
Xueyan YangDepartment of Gastroenterology, The Affiliated Hospital of Yunnan University Kunming, Yunnan, China.
Lixian BaiDepartment of Pediatrics, People's Hospital of Yuxi City Yuxi, Yunnan, China.
Zhongkun RenDepartment of Neurosurgery, The First Affiliated Hospital of Kunming Medical University Kunming, Yunnan, China.
Hong GongDepartment of Proctology, The Affiliated Hospital of Yunnan University Kunming, Yunnan, China.
Yinghui ZhangDepartment of Gastroenterology, The Affiliated Hospital of Yunnan University Kunming, Yunnan, China.
Han ChenDepartment of Gastroenterology, The Affiliated Hospital of Yunnan University Kunming, Yunnan, China.
Zhijian MaDepartment of Sports Medicine, The First People's Hospital of Kunming Kunming, Yunnan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver cancer, a primary malignancy of liver cells, exhibits high morbidity and mortality. Family with sequence similarity 64, member A (FAM64A) acts as an oncogene and modulates tumor progression in multiple cancers. However, the specific role of FAM64A in liver cancer development remains poorly elucidated. Thus, this work uncovered the action of FAM64A on liver cancer pathogenesis and cancer immunity and reveals the underlying mechanism. In this study, the FAM64A expression in liver cancer and its association with the overall survival were investigated using bioinformatics analysis. Tumor tissues and adjacent normal tissues were obtained from 64 liver cancer cases. Cell viability, invasion, and angiogenesis were assessed by CCK-8 method, Transwell invasion assay, and tube formation assay, respectively. The secretion levels of IFN-γ, IL-2, IL-10 and TGF-β were tested utilizing the ELISA assay. A xenograft tumor was created to monitor tumor growth

Indexed as

angiogenesisFAM64Aimmune escapeinvasionLiver cancerVEGFA/AKT pathway

Identifiers

PMID42597234
PMCPMC13468255

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.