Evidence mapPaperPMID 42597287Full record

ReviewFrontiers in neuroscience2026

MiR-7 in neurological disorders: beyond metabolic dysregulation.

Cristina Puigdueta, Virginia Pardo-Marqués, Marta Torrecilla-Parra, Mario Fernández-de Frutos, José L López-Aceituno, Carmen Zamora, Yaiza López-Manchedo, Rebeca Busto, Cristina M Ramírez

Abstract readReview
In one paragraph

Review in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cristina PuigduetaPosttranscriptional Regulation of Metabolic Diseases Laboratory, Department of Precision Nutrition and Aging, IMDEA Nutrition Research Institute, Madrid, Spain.
Virginia Pardo-MarquésPosttranscriptional Regulation of Metabolic Diseases Laboratory, Department of Precision Nutrition and Aging, IMDEA Nutrition Research Institute, Madrid, Spain.
Marta Torrecilla-ParraPosttranscriptional Regulation of Metabolic Diseases Laboratory, Department of Precision Nutrition and Aging, IMDEA Nutrition Research Institute, Madrid, Spain.
Mario Fernández-de FrutosPosttranscriptional Regulation of Metabolic Diseases Laboratory, Department of Precision Nutrition and Aging, IMDEA Nutrition Research Institute, Madrid, Spain.
José L López-AceitunoPosttranscriptional Regulation of Metabolic Diseases Laboratory, Department of Precision Nutrition and Aging, IMDEA Nutrition Research Institute, Madrid, Spain.
Carmen ZamoraPosttranscriptional Regulation of Metabolic Diseases Laboratory, Department of Precision Nutrition and Aging, IMDEA Nutrition Research Institute, Madrid, Spain.
Yaiza López-ManchedoIMDEA Nutrition Research Institute, Madrid, Spain.
Rebeca BustoDepartment of Biochemistry-Research, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.
Cristina M RamírezPosttranscriptional Regulation of Metabolic Diseases Laboratory, Department of Precision Nutrition and Aging, IMDEA Nutrition Research Institute, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain health depends on the fine coordination of metabolic and neuronal pathways, and disturbances in this balance are recognized as major drivers of neurodegenerative, neurological, and neuropsychiatric disorders. Increasing evidence indicates that microRNAs (miRNAs), as key post-transcriptional regulators of gene expression, play important roles in the molecular networks underlying neurological diseases by modulating pathways involved in energy metabolism, inflammation, oxidative stress, and neuronal survival. Among them, miR-7 has emerged as a particularly relevant regulator due to its high conservation, abundant expression in the central nervous system (CNS), and pleiotropic actions impacting both metabolic and neurodegenerative processes. This review focuses on current knowledge regarding miR-7 as a molecular node linking metabolic imbalance to neurological dysfunction, highlighting its regulatory targets and potential translational relevance in neurometabolic disorders.

Indexed as

brain diseasesmetabolismmiR-7neurodegenerationphysiological functionposttranscriptional regulationtumor suppressor

Identifiers

PMID42597287
PMCPMC13468813

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.