Evidence mapPaperPMID 42597366Full record

ArticleFrontiers in cellular neuroscience2026

Selective retinal neuron loss and impaired neurovascular support underlie myopic retinopathy in RPE-specific Lrp2-deficient mice.

Jinyan Qi, Xuexue Cui, Caijiao Yi, Jian Liu, Wen Deng, Xiang-Ling Yuan, Yuanyuan Hu, Tong Wang, Heping Xu

Abstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jinyan QiAier Eye Institute, Changsha Aier Eye Hospital, Changsha, Hunan, China.
Xuexue CuiAier Eye Institute, Changsha Aier Eye Hospital, Changsha, Hunan, China.
Caijiao YiAier Eye Institute, Changsha Aier Eye Hospital, Changsha, Hunan, China.
Jian LiuAier Eye Institute, Changsha Aier Eye Hospital, Changsha, Hunan, China.
Wen DengAier Eye Institute, Changsha Aier Eye Hospital, Changsha, Hunan, China.
Xiang-Ling YuanAier Eye Institute, Changsha Aier Eye Hospital, Changsha, Hunan, China.
Yuanyuan HuAier Eye Institute, Changsha Aier Eye Hospital, Changsha, Hunan, China.
Tong WangAier Eye Institute, Changsha Aier Eye Hospital, Changsha, Hunan, China.
Heping XuAier Eye Institute, Changsha Aier Eye Hospital, Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathologic myopia is a major cause of irreversible visual impairment worldwide and is characterized by excessive axial elongation accompanied by progressive retinal degeneration. Whether vision loss results primarily from passive retinal stretching or selective neurodegeneration remains unclear, hindering the development of effective neuroprotective and regenerative therapies. Here, we investigated retinal neuronal, vascular, and glial alterations in retinal pigment epithelium (RPE)-specific Lrp2 knockout (Best1-Cre/Lrp2

Indexed as

axial elongationmicrogliamicrovascular degeneratonneurodegenerationpathologic myopia

Identifiers

PMID42597366
PMCPMC13467757

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.