ArticleFrontiers in nutrition2026
Association of TyG-BMI and malnutrition with reduced survival outcomes in patients with cancer: a prospective study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Several triglyceride-glucose (TyG)-related indices are used to assess insulin resistance (IR), but the better indicator for patients with cancer remains undetermined. The prognostic value of TyG-body mass index (TyG-BMI), its association with malnutrition, and underlying mediating mechanisms in large Chinese multicenter cohorts need further clarification. Methods: This prospective, multicenter study enrolled 5,221 patients with cancer from the INSCOC cohort. We compared the prognostic performance of TyG-BMI with other TyG-related IR indices. Logistic regression was used to explore the relationship between TyG-BMI and malnutrition (PGSGA). Cox regression and mediation analyses were performed to evaluate prognostic value and mediating pathways. Results: TyG-BMI was identified as a useful indicator TyG-related IR index, with the highest time-dependent AUC values and C-index. High TyG-BMI was independently associated with better overall survival (adjusted HR = 0.83, 95%CI: 0.76-0.91, Conclusion: TyG-BMI, a simple composite index based on routine clinical indicators, is a TyG-related insulin resistance index for Chinese patients with cancer. High TyG-BMI is significantly associated with a lower risk of malnutrition and better overall survival. Exploratory pathway analyses indicated nutritional status, systemic inflammation and physical function partially contributed to the crude correlation between TyG-BMI and survival. TyG-BMI and malnutrition are jointly associated with reduced survival outcomes in patients with cancer, supporting its clinical value for prognostic stratification and nutritional-metabolic management.
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