Evidence map›Paper›PMID 42597483›Full record

ReviewFrontiers in aging2026

Advances in anti-aging Drug research leveraging multi-omics and artificial intelligence.

Lijuan Gao, Yongsheng Qin, Yudai Xu, Ju Su, Zhicheng Cai, Zhongyu Hu, Ruohu Shi, Xinyi Mu, Shiying Cen, Chanchan Xiao and 1 more

Abstract readReview
In one paragraph

Review in Frontiers in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lijuan Gao *Department of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China.
Yongsheng Qin *School of Environmental Engineering, Guangdong Polytechnic of Environment Protection Engineering, Foshan, Guangdong, China.
Yudai Xu *The Sixth Affiliated Hospital of Jinan University (Dongguan Eastern Central Hospital), Jinan University, Dongguan, Guangdong, China.
Ju SuFirst Affiliated Hospital, Jinan University, Guangzhou, Guangdong, China.
Zhicheng CaiDepartment of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China.
Zhongyu HuDepartment of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China.
Ruohu ShiDepartment of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China.
Xinyi MuDepartment of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China.
Shiying CenOffice of Scientific Research and Development, Jinan University, Guangzhou, Guangdong, China.
Chanchan XiaoFirst Affiliated Hospital, Jinan University, Guangzhou, Guangdong, China.
Guobing ChenDepartment of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intensifying global population aging has rendered the development of anti-aging drugs a core challenge in the life sciences domain. Traditional models struggle to address the systemic and networked nature of aging. Multi-omics technologies provide a panoramic perspective for deciphering molecular networks of aging, while Artificial Intelligence (AI) has demonstrated significant advantages in target discovery, drug screening, and clinical trial optimization. This review systematically elaborates on the pathological characteristics and molecular mechanisms of aging, analyzes the application paradigms of multi-omics in biomarker screening, mechanism elucidation, and high-throughput screening, and discusses the core value and technical bottlenecks of AI in target prediction, virtual screening, and trial design. Simultaneously, this paper addresses critical challenges including ethical controversies and data standardization currently confronting the field, and explores the prospects of precision anti-aging drug development and personalized treatment strategies driven by deep integration of multi-omics and AI. This approach offers novel theoretical frameworks and practical pathways for extending human healthspan.

Indexed as

Anti-aging drugsartificial intelligenceclinical translationdrug screeningmulti-omics

Identifiers

PMID42597483
PMCPMC13469437

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.