ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2026
Association Between Short-Term Glycemic Variability Measured by Continuous Glucose Monitoring and Early Diabetic Kidney Disease in Type 2 Diabetes.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The role of short‑term glycemic variability (GV) in early diabetic kidney disease (DKD) among patients with type 2 diabetes (T2D) remains controversial. This study aims to investigate the independent association between continuous glucose monitoring (CGM)-derived GV indices and early DKD in T2D patients. Methods: This cross-sectional study included 315 patients with T2D. Early DKD was identified as persistent microalbuminuria (urine albumin-to-creatinine ratio 30-300 mg/g) with preserved renal function (eGFR≥60 mL/min/1.73 m Results: Participants with early DKD had significantly higher MAGE and SDBG (both Conclusion: CGM-derived short-term GV indices MAGE and SDBG are independently associated with early DKD in T2D patients, with distinct dose-response patterns: MAGE shows a linear positive relationship, whereas SDBG exhibits a U-shaped association. Moreover, the MAGE-DKD association is confined to overweight individuals. Prospective studies are needed to establish causality and to verify whether personalized targeting of short‑term GV might be associated with lower DKD risk.
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