Evidence map›Paper›PMID 42597674›Full record

ArticleEClinicalMedicine2026

The effect of normothermic machine perfusion on acute kidney injury following liver transplantation: a propensity score-matched, retrospective, single-centre, cohort study.

Muhammad Ahmad Nadeem, Chase J Wehrle, Sangeeta Satish, Mingyi Zhang, Puneet Bansal, Khaled Ali, Ahmed Hussein, Sapana Verma, Valberto Sanha, Rebecca Panconesi and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Muhammad Ahmad NadeemCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH, USA.
Chase J WehrleCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH, USA.
Sangeeta SatishCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH, USA.
Mingyi ZhangCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH, USA.
Puneet BansalCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH, USA.
Khaled AliCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH, USA.
Ahmed HusseinDepartment of Liver Transplantation, Cleveland Clinic Weston Hospital, Weston, FL, USA.
Sapana VermaCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH, USA.
Valberto SanhaCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH, USA.
Rebecca PanconesiCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH, USA.
Chunbao JiaoCleveland Clinic, Department of Inflammation & Immunology, Lerner Research Institute, Cleveland, OH, USA.
Keyue SunCleveland Clinic, Department of Inflammation & Immunology, Lerner Research Institute, Cleveland, OH, USA.
Omer Karuk KarakayaCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH, USA.
Geofia S CrastaCleveland Clinic, Department of Inflammation & Immunology, Lerner Research Institute, Cleveland, OH, USA.
Fatma Selin YildirimCleveland Clinic, Department of Inflammation & Immunology, Lerner Research Institute, Cleveland, OH, USA.
Mazhar KhalilCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH, USA.
Alejandro PitaCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH, USA.
Jamak Modaresi EsfehCleveland Clinic, Department of Hepatology, Digestive Disease & Surgery Institute, Cleveland, OH, USA.
David C H KwonCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH, USA.
Federico AucejoCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH, USA.
Jaekeun KimCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH, USA.
Robert L FairchildCleveland Clinic, Department of Inflammation & Immunology, Lerner Research Institute, Cleveland, OH, USA.
Antonio D PinnaDepartment of Liver Transplantation, Cleveland Clinic Weston Hospital, Weston, FL, USA.
Bijan EghtesadCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH, USA.
Richard A FaticaDepartment of Kidney Medicine, Cleveland Clinic, Cleveland, OH, USA.
Charles MillerCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH, USA.
Masato FujikiCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH, USA.
Koji HashimotoCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH, USA.
Andrea SchlegelCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Normothermic machine perfusion (NMP) is increasingly used for liver transplantation, but its effect on post-transplantation acute kidney injury (AKI), especially in recipients with renal dysfunction, remains unclear. We evaluated whether NMP was associated with lower early renal injury after deceased donor liver transplantation compared with static cold storage (SCS), including recipients with pre-existing AKI or chronic kidney disease (CKD). Methods: This retrospective, single-centre, cohort study at Cleveland Clinic included deceased donor liver transplantation recipients transplanted between January 2019 and January 2025 with at least 12 months of follow-up. The primary outcome was new post-transplantation AKI by KDIGO serum creatinine criteria. Renal outcomes were assessed using KDIGO staging and validated core outcome set endpoints. Associations were evaluated using mixed-effects logistic regression, and NMP recipients were matched 1:1 to SCS recipients using propensity scores. Findings: 893 recipients were included; 319 (36%) received NMP. In multivariable analysis, NMP was associated with lower odds of AKI (odds ratio [OR] 0.70, 95% CI 0.46-0.94; p = 0.036) and new renal replacement therapy (RRT; OR 0.10, 95% CI 0.017-0.64; p = 0.015). Among 213 matched pairs without pre-existing AKI or CKD, AKI occurred in 62 (29%) NMP recipients vs 88 (41%) SCS recipients (p = 0.008), acute kidney disease in 95 (45%) vs 122 (57%; p = 0.009), and stage 3 AKI in seven (3%) vs 15 (7%). Among recipients with pre-existing AKI or CKD, postoperative peak creatinine was lower with NMP in unmatched (2.22 mg/dL [IQR 1.72-2.86] vs 2.71 mg/dL [1.85-3.47]; p = 0.017) and matched cohorts (2.04 mg/dL [1.64-2.34] vs 2.87 mg/dL [2.65-3.34]; p < 0.001). Interpretation: NMP was associated with a modest but clinically relevant reduction in early renal injury after liver transplantation. These effects were most pronounced in recipients without pre-existing renal dysfunction and remained directionally consistent in high-risk recipients. Funding: None.

Indexed as

Acute kidney injuryLiver transplantationNormothermic machine perfusionRenal dysfunctionRenal replacement therapyStatic cold storage

Identifiers

PMID42597674
PMCPMC13470095

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.