Evidence map›Paper›PMID 42597725›Full record

ArticleMetabolism open2026

Empagliflozin inhibits the apoptosis of pancreatic β-cells through amelioration of endoplasmic reticulum (ER) stress.

Narjes Nasiri-Ansari, Manpal S Randeva, Christina-Maria Flessa, Ioannis Kyrou, Panagiotis Lembessis, Hippokratis Kiaris, Maria-Eleni Chondrogianni, Maria Dalamaga, Athanasios G Papavassiliou, Harpal S Randeva and 1 more

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Article in Metabolism open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Narjes Nasiri-AnsariDepartment of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, Athens, 11527, Greece.
Manpal S RandevaWarwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, CV2 2DX, UK.
Christina-Maria FlessaDepartment of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, Athens, 11527, Greece.
Ioannis KyrouWarwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, CV2 2DX, UK.
Panagiotis LembessisDepartment of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens, 11527, Greece.
Hippokratis KiarisDepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, 29208, United States.
Maria-Eleni ChondrogianniDepartment of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, Athens, 11527, Greece.
Maria DalamagaDepartment of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, Athens, 11527, Greece.
Athanasios G PapavassiliouDepartment of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, Athens, 11527, Greece.
Harpal S RandevaWarwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, CV2 2DX, UK.
Eva KassiDepartment of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, Athens, 11527, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Progressive loss of pancreatic β-cell function in type 2 diabetes mellitus (T2DM) is linked to endoplasmic reticulum (ER) stress-induced apoptosis. Sodium-glucose cotransporter-2 inhibitors (SGLT-2i) have glucose-lowering and potential cytoprotective effects. We investigated whether empagliflozin protects β-cells from ER stress-mediated apoptosis and the underlying pathway. Methods: Mouse Beta-TC-6 (BTC-6) and hamster HIT-T15 pancreatic β-cell lines were exposed to tunicamycin (5 or 10 μg/mL) to induce ER stress, with or without empagliflozin (10 Results: BTC-6 cells expressed Conclusions: Empagliflozin enhances β-cell proliferation and attenuates ER stress-induced apoptosis

Indexed as

ApoptosisEmpagliflozinEndoplasmic reticulum (ER)ER stressNecrosisPancreatic β-cellsSGLT-2i

Identifiers

PMID42597725
PMCPMC13470530

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.