Evidence map›Paper›PMID 42597752›Full record

ArticleiScience2026

Microtubule-dependent regulation of chromatin dynamics by the Smc5/6 complex.

Ànnia Carré-Simon, Cecilia Martuzzi, Sarah Isler, Renaud Batrin, Henrik Dahl Pinholt, Timothy Földes, Guillaume Laflamme, Juan Reguera, Maria Barbi, Leonid Mirny and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ànnia Carré-SimonUniversité Paris Cité, INSERM, CNRS, IRSL, UMR1342, EMR8000, Paris, France.
Cecilia MartuzziUniversité Paris Cité, INSERM, CNRS, IRSL, UMR1342, EMR8000, Paris, France.
Sarah IslerOttawa Institute of Systems Biology, Department of Cellular and Molecular Medicine, Ottawa, ON, Canada.
Renaud BatrinUniversité Paris Cité, INSERM, CNRS, IRSL, UMR1342, EMR8000, Paris, France.
Henrik Dahl PinholtDepartment of Physics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Timothy FöldesSorbonne Université, CNRS, LPTMC, Paris, France.
Guillaume LaflammeOttawa Institute of Systems Biology, Department of Cellular and Molecular Medicine, Ottawa, ON, Canada.
Juan RegueraUniversité -Marseille, CNRS, UMR7257, Marseille, France.
Maria BarbiSorbonne Université, CNRS, LPTMC, Paris, France.
Leonid MirnyDepartment of Physics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Damien D'AmoursOttawa Institute of Systems Biology, Department of Cellular and Molecular Medicine, Ottawa, ON, Canada.
Emmanuelle FabreUniversité Paris Cité, INSERM, CNRS, IRSL, UMR1342, EMR8000, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proper centromeres and pericentromeres folding is crucial for maintaining genome integrity and ensuring accurate chromosome segregation. Smc5/6 complex, which localizes at pericentromeres, can bind microtubules, yet its role in chromatin folding is unclear. Here, we investigate the functional relevance of Smc5/6 binding to microtubules in yeast using a separation-of-function mutant (

Indexed as

chromatin dynamicsDNA double-strand break repairmicrotubulesmitotic spindlepericentromeresSmc5/6

Identifiers

PMID42597752
PMCPMC13470446

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.