Evidence map›Paper›PMID 42597837›Full record

ArticleFrontiers in endocrinology2026

Remission of polycystic ovary syndrome based on the recovery of ovarian morphology identified by three-dimensional ultrasonography: a retrospective study.

Keying Su, Yujie Zhao, Huihui Chai, Meili Cai, Diliqingna Dilimulati, Yuqin Zhang, Xiaowen Shao, Shen Qu, Chang Liu, Manna Zhang

Registry-linked trialAbstract read
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In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05063383 (Analysis of Clinical Characteristics and Study of Diagnostic Markers in Patients with Polycystic Ovary Syndrome), which is not on this map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05063383 unknown statusnot on this map

Analysis of Clinical Characteristics and Study of Diagnostic Markers in Patients with Polycystic Ovary Syndrome

TypeobservationalSponsorShanghai 10th People's HospitalRan2019 to 2025Enrolled600ConditionsPolycystic Ovary SyndromeArmsThis study does not involve any interventions
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Keying Su *Department of Laboratory Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yujie Zhao *Department of General Practice, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Huihui Chai *Department of Medical Ultrasound, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Meili CaiDepartment of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Diliqingna DilimulatiDepartment of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yuqin ZhangDepartment of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Xiaowen ShaoDepartment of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Shen QuDepartment of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Chang LiuDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Manna ZhangDepartment of General Practice, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Polycystic ovary syndrome (PCOS) is a prevalent chronic disease, yet the concept of PCOS remission and its predictors remain poorly understood. Objectives: This study investigated PCOS remission rates via three-dimensional (3D) ultrasonography assessment of ovarian morphological normalization. Methods: This retrospective study included 1379 reproductive-aged PCOS women from Shanghai Tenth People's Hospital (Aug. 2019-Dec. 2025). After medication initiation, anthropometric, biochemical, and reproductive data (both baseline and post-treatment) were collected quarterly, while 3D ultrasonography was used to evaluate polycystic morphology during follow-up. Results: Among the 468 eligible participants, 55 (11.75%) achieved clinical remission of PCOS, defined as restoration of regular menses, normalization of serum testosterone levels, and recovery of normal ovarian morphology. The mean time to remission was 12.76 ± 11.77 months. Patients in the clinical remission group were frequently prescribed insulin-sensitizing and weight-loss agents, including metformin, glucagon-like peptide-1 receptor agonists (GLP-1 RAs), sodium-glucose linked transporter 2 inhibitors (SGLT-2is), and thiazolidinediones (TZDs). Following treatment, the remission group exhibited significant increases in menstrual cycle frequency and estradiol (E2), together with significant reductions in body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transpeptidase (γ-GT), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), uric acid (UA), total testosterone (TT), androstenedione, and anti-Müllerian hormone (AMH) compared with baseline. Significant decreases in bilateral ovarian volume and follicle number were also observed. After adjustment for multiple confounding factors, multivariate Cox proportional hazards regression revealed that BMI, ALT, and LDL-c retained strong independent predictive value for PCOS remission. Conclusion: Our study demonstrated that 11.75% of women with PCOS achieved complete clinical remission following targeted metabolic pharmacotherapy, as evidenced by restored ovarian morphology, normalized testosterone concentrations, and regular menstrual cycles. Clinical Trial Registration: http://www.chictr.org.cn, identifier: NCT05063383.

Indexed as

Imaging, Three-DimensionalOvaryPolycystic Ovary SyndromeAdultFemaleHumansRemission InductionRetrospective StudiesTestosteroneUltrasonographyYoung AdultTestosteronemetabolic disorderpolycystic ovarian morphologypolycystic ovary syndromeremissionthree-dimensional ultrasonography

Identifiers

PMID42597837
PMCPMC13469636

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.