Evidence map›Paper›PMID 42597876›Full record

ArticleACS omega2026

Biocompatible Cyclodextrin-Cannabinoid Agar-Xanthan Gum Hydrogels for Controlled Delivery and Antimicrobial Soft-Tissue Biomedical Applications.

Camilo Zamora-Ledezma, Dulexy Solano-Orrala, Daniel Peña-Jimenez, Sandra Herranz-Gómez, Dennis A Silva-Cullishpuma, María Teresa Mercader-Ros, Giovanna Gomez d'Ayala, Donatella Duraccio, Duncan John Mowbray, Stephanie Marina Díaz-López and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Camilo Zamora-LedezmaBioengineering & Regenerative Medicine Research Group (Bio-ReM), Escuela de Ingeniería, Arquitectura y Diseño (EIAD), Universidad Alfonso X el Sabio (UAX). Avenida de la Universidad 1, Villanueva de la Cañada, 28691 Madrid, Spain.ORCID https://orcid.org/0000-0002-8704-1539
Dulexy Solano-OrralaBioengineering & Regenerative Medicine Research Group (Bio-ReM), Escuela de Ingeniería, Arquitectura y Diseño (EIAD), Universidad Alfonso X el Sabio (UAX). Avenida de la Universidad 1, Villanueva de la Cañada, 28691 Madrid, Spain.
Daniel Peña-JimenezUnidad de Investigación Biomédica (UIB-UAX), Universidad Alfonso X el Sabio (UAX). Avenida de la Universidad 1, Villanueva de la Cañada, 28691 Madrid, Spain.ORCID https://orcid.org/0000-0002-3192-464X
Sandra Herranz-GómezUnidad de Terapias Farmacológicas, Área de Genética Humana, Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Dennis A Silva-CullishpumaNutrition, Food and Health (NAS). Faculty of Pharmacy and Nutrition, UCAM-Universidad Católica de Murcia, Avda, Los Jerónimos 135, Guadalupe, 30107 Murcia, Spain.
María Teresa Mercader-RosNutrition, Food and Health (NAS). Faculty of Pharmacy and Nutrition, UCAM-Universidad Católica de Murcia, Avda, Los Jerónimos 135, Guadalupe, 30107 Murcia, Spain.
Giovanna Gomez d'AyalaInstitute of Polymers, Composites and Biomaterials (IPCB), National Research Council, Via Campi Flegrei, 34, Pozzuoli, 80078 Naples, Italy.
Donatella DuraccioInstitute of Sciences and Technologies for Sustainable Energy and Mobility, National Research Council of Italy. Local Branch, Strada delle cacce, 73, 10135 Torino, Italy.
Duncan John MowbraySchool of Physical Sciences and Nanotechnology, Yachay Tech University, 100119 Urcuquí, Ecuador.ORCID https://orcid.org/0000-0002-8520-0364
Stephanie Marina Díaz-LópezLaboratorio Funcionamiento de Agroecosistemas y Cambio Climático FAGROCLIM, Departamento de Ciencias Agrícola, Facultad de Ingeniería Agrícola, Universidad Técnica de Manabí, Lodana 13132, Ecuador.
Frank AlexisDepartamento de Ingenieria Quimica, Colegio de Ciencias e Ingenieria, Institute for Energy and Materials, Universidad San Francisco de Quito USFQ, Quito 170901, Ecuador.ORCID https://orcid.org/0000-0002-0597-7940
Carmen Lucas-AbellánNutrition, Food and Health (NAS). Faculty of Pharmacy and Nutrition, UCAM-Universidad Católica de Murcia, Avda, Los Jerónimos 135, Guadalupe, 30107 Murcia, Spain.ORCID https://orcid.org/0000-0002-8655-4156

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Agar/xanthan hydrogels incorporating hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complexes of nonpsychoactive cannabinoids (cannabidiol, CBD; cannabinol, CBN) were developed as multifunctional biomaterials for controlled delivery and antimicrobial soft-tissue biomedical applications. Physicochemical characterization showed improved thermal stability, tunable hydrophilicity, and a porous network suitable for loading and release. In vitro release studies demonstrated sustained cannabinoid delivery over 72 h, following first-order and Fu-Kao kinetic models. The hydrogels exhibited selective antimicrobial activity against

Identifiers

PMID42597876
PMCPMC13470697

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.